Effect of sildenafil on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction

被引：30

作者：

Cavalcanti, Ana L. ^{[1
]}

Bagnoli, Vicente R. ^{[1
]}

Fonseca, Angela M. ^{[1
]}

Pastore, Roberto A. ^{[2
]}

Cardoso, Eduardo B. ^{[1
]}

Paixao, Jucilene S. ^{[1
]}

Soares, Jose M., Jr. ^{[1
]}

Saad, Fabricio ^{[1
]}

Baracat, Edmund C. ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Obstet & Gynecol, BR-05508 Sao Paulo, Brazil

[2] Univ Sao Paulo, Dept Radiol, Sao Paulo, Brazil

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 2008年 / 102卷 / 02期

关键词：

clitoral blood flow; menopause; orgasmic dysfunction; sexual function; sildenafil citrate;

D O I：

10.1016/j.ijgo.2008.03.020

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To analyze the effects of sildenafil citrate on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction. Method: In this randomized, double-blind, placebo-controlled trial 22 women received a 50-mg dose of sildenafil (n=11) or placebo (n=11) daily for 15 days. The Golombok Rust Inventory of Sexual Satisfaction (GRISS) was used for subjective evaluation of the sexual-response cycle. Clitoral blood flow was measured by color and pulse Doppler at baseline, after 1 hour of taking the first dose, and after 15 days of treatment. Results: Blood flow was significantly more improved in the sildenafit than in the placebo group (P<0.05), and a positive correlation between Doppler values and GRISS scores was noted in the sildenafil group after only 15 days of treatment. Conclusion: Sildenafil may improve clitoral blood flow and increase the GRISS scores in postmenopausal women with orgasmic dysfunction. (C) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：115 / 119

页数：5

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