Enantioselective synthesis of levomilnacipran

被引：30

作者：

Alliot, Julien ^{[1
]}

Gravel, Edmond ^{[1
]}

Pillon, Florence ^{[1
]}

Buisson, David-Alexandre ^{[1
]}

Nicolas, Marc ^{[2
]}

Doris, Eric ^{[1
]}

机构：

[1] CEA, iBiTecS, Serv Chim Bioorgan & Marquage, F-91191 Gif Sur Yvette, France

[2] Les Labs Pierre Fabre, Ctr Dev Chim Ind, F-81600 Gaillac, France

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 65期

关键词：

NMDA RECEPTOR ANTAGONISTS; MILNACIPRAN ANALOGS; ACIDS; NOREPINEPHRINE; ANTIDEPRESSANT; SELECTIVITY; SEROTONIN;

D O I：

10.1039/c2cc33743f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel approach for the asymmetric synthesis of the active (1S,2R)-enantiomer of the antidepressant milnacipran is reported. The two stereogenic centers borne by the cyclopropane ring were sequentially installed starting from phenylacetic acid.

引用

页码：8111 / 8113

页数：3

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