The cGMP Signaling Pathway as a Therapeutic Target in Heart Failure With Preserved Ejection Fraction

被引：120
|
作者：
Greene, Stephen J. [1 ]
Gheorghiade, Mihai [1 ]
Borlaug, Barry A. [2 ]
Pieske, Burkert [3 ]
Vaduganathan, Muthiah [4 ]
Burnett, John C., Jr. [2 ]
Roessig, Lothar [5 ]
Stasch, Johannes-Peter [6 ]
Solomon, Scott D. [7 ]
Paulus, Walter J. [8 ]
Butler, Javed [9 ]
机构：
[1] Northwestern Univ, Feinberg Sch Med, Ctr Cardiovasc Innovat, Chicago, IL 60611 USA
[2] Mayo Clin & Mayo Fdn, Div Cardiovasc Dis, Rochester, MN USA
[3] Med Univ Graz, Dept Cardiol, Graz, Austria
[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med, Boston, MA USA
[5] Bayer Pharma AG, Berlin, Germany
[6] Bayer HealthCare, Cardiol Res, Wuppertal, Germany
[7] Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA
[8] Vrije Univ Amsterdam, Med Ctr Amsterdam, Dept Physiol, Inst Cardiovasc Res VU, Amsterdam, Netherlands
[9] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA
来源：
JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2013年 / 2卷 / 06期
关键词：
cGMP; heart failure; phosphodiesterase; 5; preserved ejection fraction; soluble guanylate cyclase; SOLUBLE GUANYLATE-CYCLASE; NITRIC-OXIDE SYNTHASE; IMPROVES EXERCISE CAPACITY; PULMONARY-HYPERTENSION; NATRIURETIC PEPTIDE; PHOSPHODIESTERASE-5; INHIBITION; DIASTOLIC DISTENSIBILITY; ENDOTHELIAL DYSFUNCTION; SODIUM-NITROPRUSSIDE; CONTRACTILE RESPONSE;
D O I：
10.1161/JAHA.113.000536
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
[No abstract available]
引用
收藏
页数：11
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