The cGMP Signaling Pathway as a Therapeutic Target in Heart Failure With Preserved Ejection Fraction

被引：122
作者：
Greene, Stephen J. [1 ]
Gheorghiade, Mihai [1 ]
Borlaug, Barry A. [2 ]
Pieske, Burkert [3 ]
Vaduganathan, Muthiah [4 ]
Burnett, John C., Jr. [2 ]
Roessig, Lothar [5 ]
Stasch, Johannes-Peter [6 ]
Solomon, Scott D. [7 ]
Paulus, Walter J. [8 ]
Butler, Javed [9 ]
机构：
[1] Northwestern Univ, Feinberg Sch Med, Ctr Cardiovasc Innovat, Chicago, IL 60611 USA
[2] Mayo Clin & Mayo Fdn, Div Cardiovasc Dis, Rochester, MN USA
[3] Med Univ Graz, Dept Cardiol, Graz, Austria
[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med, Boston, MA USA
[5] Bayer Pharma AG, Berlin, Germany
[6] Bayer HealthCare, Cardiol Res, Wuppertal, Germany
[7] Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA
[8] Vrije Univ Amsterdam, Med Ctr Amsterdam, Dept Physiol, Inst Cardiovasc Res VU, Amsterdam, Netherlands
[9] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA
来源：
JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2013年 / 2卷 / 06期
关键词：
cGMP; heart failure; phosphodiesterase; 5; preserved ejection fraction; soluble guanylate cyclase; SOLUBLE GUANYLATE-CYCLASE; NITRIC-OXIDE SYNTHASE; IMPROVES EXERCISE CAPACITY; PULMONARY-HYPERTENSION; NATRIURETIC PEPTIDE; PHOSPHODIESTERASE-5; INHIBITION; DIASTOLIC DISTENSIBILITY; ENDOTHELIAL DYSFUNCTION; SODIUM-NITROPRUSSIDE; CONTRACTILE RESPONSE;
D O I：
10.1161/JAHA.113.000536
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
[No abstract available]
引用
收藏
页数：11
相关论文
共 111 条
[71]   Comparison of omapatrilat chronic and enalapril in patients with heart failure - The omapatrilat versus enalapril randomized trial of utility in reducing events (OVERTURE) [J].
Packer, M ;
Califf, RM ;
Konstam, MA ;
Krum, H ;
McMurray, JJ ;
Rouleau, JL ;
Swedberg, K .
CIRCULATION, 2002, 106 (08) :920-926
[72]   A Novel Paradigm for Heart Failure With Preserved Ejection Fraction Comorbidities Drive Myocardial Dysfunction and Remodeling Through Coronary Microvascular Endothelial Inflammation [J].
Paulus, Walter J. ;
Tschoepe, Carsten .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2013, 62 (04) :263-271
[73]   Treatment of Heart Failure With Normal Ejection Fraction An Inconvenient Truth! [J].
Paulus, Walter J. ;
van Ballegoij, Joris J. M. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2010, 55 (06) :526-537
[74]   Nitric oxide's role in the heart: control of beating or breathing? [J].
Paulus, WJ ;
Bronzwaer, JGF .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2004, 287 (01) :H8-H13
[75]   ACUTE EFFECTS OF NITRIC-OXIDE ON LEFT-VENTRICULAR RELAXATION AND DIASTOLIC DISTENSIBILITY IN HUMANS - ASSESSMENT BY BICORONARY SODIUM-NITROPRUSSIDE INFUSION [J].
PAULUS, WJ ;
VANTRIMPONT, PJ ;
SHAH, AM .
CIRCULATION, 1994, 89 (05) :2070-2078
[76]   Defects in cGMP-PKG pathway contribute to impaired NO-dependent responses in hepatic stellate cells upon activation [J].
Perri, RE ;
Langer, DA ;
Chatterjee, S ;
Gibbons, SJ ;
Gadgil, J ;
Cao, S ;
Farrugia, G ;
Shah, VH .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2006, 290 (03) :G535-G542
[77]   Expression and activity of soluble guanylate cyclase in injury and repair of anti-thy1 glomerulonephritis [J].
Peters, H ;
Wang, YR ;
Loof, TJ ;
Martini, S ;
Kron, S ;
Krämer, S ;
Neumayer, HH .
KIDNEY INTERNATIONAL, 2004, 66 (06) :2224-2236
[78]   Natriuretic peptides, their receptors, and cyclic guanosine monophosphate-dependent signaling functions [J].
Potter, LR ;
Abbey-Hosch, S ;
Dickey, DM .
ENDOCRINE REVIEWS, 2006, 27 (01) :47-72
[79]   NITRIC-OXIDE AS A MEDIATOR OF RELAXATION OF THE CORPUS CAVERNOSUM IN RESPONSE TO NONADRENERGIC, NONCHOLINERGIC NEUROTRANSMISSION [J].
RAJFER, J ;
ARONSON, WJ ;
BUSH, PA ;
DOREY, FJ ;
IGNARRO, LJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (02) :90-94
[80]   Experimental and clinical basis for the use of statins in patients with ischemic and nonischemic cardiomyopathy [J].
Ramasubbu, Kumudha ;
Estep, Jerry ;
White, Donna L. ;
Deswal, Anita ;
Mann, Douglas L. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (04) :415-426
3456789101112