The cGMP Signaling Pathway as a Therapeutic Target in Heart Failure With Preserved Ejection Fraction

被引：121

作者：

Greene, Stephen J. ^{[1
]}

Gheorghiade, Mihai ^{[1
]}

Borlaug, Barry A. ^{[2
]}

Pieske, Burkert ^{[3
]}

Vaduganathan, Muthiah ^{[4
]}

Burnett, John C., Jr. ^{[2
]}

Roessig, Lothar ^{[5
]}

Stasch, Johannes-Peter ^{[6
]}

Solomon, Scott D. ^{[7
]}

Paulus, Walter J. ^{[8
]}

Butler, Javed ^{[9
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Ctr Cardiovasc Innovat, Chicago, IL 60611 USA

[2] Mayo Clin & Mayo Fdn, Div Cardiovasc Dis, Rochester, MN USA

[3] Med Univ Graz, Dept Cardiol, Graz, Austria

[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med, Boston, MA USA

[5] Bayer Pharma AG, Berlin, Germany

[6] Bayer HealthCare, Cardiol Res, Wuppertal, Germany

[7] Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA

[8] Vrije Univ Amsterdam, Med Ctr Amsterdam, Dept Physiol, Inst Cardiovasc Res VU, Amsterdam, Netherlands

[9] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA

来源：

JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2013年 / 2卷 / 06期

关键词：

cGMP; heart failure; phosphodiesterase; 5; preserved ejection fraction; soluble guanylate cyclase; SOLUBLE GUANYLATE-CYCLASE; NITRIC-OXIDE SYNTHASE; IMPROVES EXERCISE CAPACITY; PULMONARY-HYPERTENSION; NATRIURETIC PEPTIDE; PHOSPHODIESTERASE-5; INHIBITION; DIASTOLIC DISTENSIBILITY; ENDOTHELIAL DYSFUNCTION; SODIUM-NITROPRUSSIDE; CONTRACTILE RESPONSE;

D O I：

10.1161/JAHA.113.000536

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页数：11

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