Rearrangement/hypermutation/gene conversion: When, where and why?

被引：79
作者：
Weill, JC
Reynaud, CA
机构：
[1] INSERM U373, Institut Necker, Université Paris 5, 75730 Paris Cedex 15
来源：
IMMUNOLOGY TODAY | 1996年 / 17卷 / 02期
关键词：
D O I：
10.1016/0167-5699(96)80586-X
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Diversification strategies for immunoglobulins vary widely in different species. Here, Jean-Claude Weill and Claude-Agnes Reynaud argue that V(D)J recombination arose as a means for achieving allelic exclusion rather than diversity, and postulate that the choice of a diversification strategy is selected along with a specific site of B-cell differentiation. They propose that somatic mutation and gene conversion represent analogous molecular strategies occurring in specific chromatin accessibility contexts.
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收藏
页码：92 / 97
页数：6
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