Rearrangement/hypermutation/gene conversion: When, where and why?

被引：79

作者：

Weill, JC

Reynaud, CA

机构：

[1] INSERM U373, Institut Necker, Université Paris 5, 75730 Paris Cedex 15

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 02期

关键词：

D O I：

10.1016/0167-5699(96)80586-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Diversification strategies for immunoglobulins vary widely in different species. Here, Jean-Claude Weill and Claude-Agnes Reynaud argue that V(D)J recombination arose as a means for achieving allelic exclusion rather than diversity, and postulate that the choice of a diversification strategy is selected along with a specific site of B-cell differentiation. They propose that somatic mutation and gene conversion represent analogous molecular strategies occurring in specific chromatin accessibility contexts.

引用

页码：92 / 97

页数：6

共 37 条

[1] GENERATION OF IMMUNOGLOBULIN LIGHT-CHAIN GENE DIVERSITY IN RAJA-ERINACEA IS NOT ASSOCIATED WITH SOMATIC REARRANGEMENT, AN EXCEPTION TO A CENTRAL PARADIGM OF B-CELL IMMUNITY [J].