A Catalytic Asymmetric Electrocyclization-Protonation Reaction

被引：107
作者：
Rueping, Magnus [1 ]
Ieawsuwan, Winai [1 ]
机构：
[1] Goethe Univ Frankfurt, Inst Organ Chem & Chem Biol, D-60438 Frankfurt, Germany
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2009年 / 351卷 / 1-2期
关键词：
Bronsted acids; cascade reaction; cyclopentenone; domino reaction; Nazarov reaction; organic catalysis; CHIRAL BRONSTED ACID; TANDEM NAZAROV CYCLIZATION; FRIEDEL-CRAFTS REACTION; SILYL ENOL ETHERS; ENANTIOSELECTIVE PROTONATION; TRANSFER HYDROGENATION; MANNICH REACTION; METAL-FREE; REDUCTION; CASCADE;
D O I：
10.1002/adsc.200800623
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The first enantioselective Bronsted acid-catalyzed electrocyclization-protonation reaction has been developed which provides a number of different cyclopentenones in good yields and with high enantioselectivities. The stereodetermining step of this asymmetric Nazarov cyclization reaction is an asymmetric Bronsted acid-catalyzed kinetic protonation.
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页码：78 / 84
页数：7
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