Synthesis of 4-aminoquinolines by aerobic oxidative palladium-catalyzed double C-H activation and isocyanide insertion

被引：18
作者：
Vlaar, T. [1 ,2 ]
Maes, B. U. W. [3 ]
Ruijter, E. [1 ,2 ]
Orru, R. V. A. [1 ,2 ]
机构：
[1] Vrije Univ Amsterdam, Dept Chem & Pharmaceut Sci, NL-1081 HV Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, AIMMS, NL-1081 HV Amsterdam, Netherlands
[3] Univ Antwerp, Dept Chem, B-2020 Antwerp, Belgium
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2013年 / 49卷 / 06期
关键词：
isocyanides; palladium; quinolines; catalysis; C-H bond activation; imidoylative cross coupling; N-ARYL ENAMINES; DERIVATIVES; 4-AMINOQUINAZOLINES; HYDROGENATION; BROMOALKYNES; HETEROCYCLES; CYCLIZATION; CLEAVAGE; ANILINES; INDOLES;
D O I：
10.1007/s10593-013-1324-z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An unprecedented aerobic oxidative Pd-catalyzed imidoylative coupling of two C-H fragments furnishing medicinally valuable 4-aminoquinolines is reported. Optimization studies are described and several analogs were successfully prepared.
引用
收藏
页码：902 / 908
页数：7
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