in vitro fertilization;
luteal support;
infertility;
estradiol;
progesterone;
pregnancy;
D O I:
10.1016/S0015-0282(16)58572-0
中图分类号:
R71 [妇产科学];
学科分类号:
100211 ;
摘要:
Objective: To determine if pregnancy rates (PRs) for clomiphene citrate (CC)-stimulated TVF-ET can be increased by luteal support with E(2) and P. Design: Prospective randomized crossover clinical study. Setting: Infertile women volunteers in an academic research environment. Patients: Ninety-three infertile women underwent a total of 143 TVF-ET cycles using CC for ovulation induction. Interventions: Each woman received either no luteal support (control group) or luteal support with both oral E(2) (2 mg three times daily) starting on the day of retrieval and vaginal P suppositories (100 mg twice daily) starting on the day of ET. Main Outcome Measure: Clinical PR. Results: In 79 of 143 (55%) of the cycles, at least one embryo was transferred. Compared with the control group (n = 35 cycles), the luteal support group (n = 44 cycles) had a significantly higher PR per retrieval (control: 2% versus luteal support: 16%) and were older (control: 33 +/- 4 versus luteal support: 35 +/- 4 years; mean +/- SEM). They did not differ in terms of E(2) or P levels, endometrial thickness on the day of hCG, number of follicles > 16 mm in diameter, mature oocytes retrieved, or embryos transferred. Conclusions: Luteal support with both E(2) and P significantly increases the clinical PRs for CC-stimulated IVF-ET.
机构:
UNIV SO CALIF,LOS ANGELES CTY WOMEN & CHILDRENS HOSP,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,LOS ANGELES,CAUNIV SO CALIF,LOS ANGELES CTY WOMEN & CHILDRENS HOSP,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,LOS ANGELES,CA
MORRIS, RS
PAULSON, RJ
论文数: 0引用数: 0
h-index: 0
机构:
UNIV SO CALIF,LOS ANGELES CTY WOMEN & CHILDRENS HOSP,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,LOS ANGELES,CAUNIV SO CALIF,LOS ANGELES CTY WOMEN & CHILDRENS HOSP,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,LOS ANGELES,CA
PAULSON, RJ
SAUER, MV
论文数: 0引用数: 0
h-index: 0
机构:
UNIV SO CALIF,LOS ANGELES CTY WOMEN & CHILDRENS HOSP,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,LOS ANGELES,CAUNIV SO CALIF,LOS ANGELES CTY WOMEN & CHILDRENS HOSP,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,LOS ANGELES,CA
SAUER, MV
LOBO, RA
论文数: 0引用数: 0
h-index: 0
机构:
UNIV SO CALIF,LOS ANGELES CTY WOMEN & CHILDRENS HOSP,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,LOS ANGELES,CAUNIV SO CALIF,LOS ANGELES CTY WOMEN & CHILDRENS HOSP,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,LOS ANGELES,CA
机构:
UNIV SO CALIF,LOS ANGELES CTY WOMEN & CHILDRENS HOSP,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,LOS ANGELES,CAUNIV SO CALIF,LOS ANGELES CTY WOMEN & CHILDRENS HOSP,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,LOS ANGELES,CA
MORRIS, RS
PAULSON, RJ
论文数: 0引用数: 0
h-index: 0
机构:
UNIV SO CALIF,LOS ANGELES CTY WOMEN & CHILDRENS HOSP,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,LOS ANGELES,CAUNIV SO CALIF,LOS ANGELES CTY WOMEN & CHILDRENS HOSP,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,LOS ANGELES,CA
PAULSON, RJ
SAUER, MV
论文数: 0引用数: 0
h-index: 0
机构:
UNIV SO CALIF,LOS ANGELES CTY WOMEN & CHILDRENS HOSP,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,LOS ANGELES,CAUNIV SO CALIF,LOS ANGELES CTY WOMEN & CHILDRENS HOSP,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,LOS ANGELES,CA
SAUER, MV
LOBO, RA
论文数: 0引用数: 0
h-index: 0
机构:
UNIV SO CALIF,LOS ANGELES CTY WOMEN & CHILDRENS HOSP,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,LOS ANGELES,CAUNIV SO CALIF,LOS ANGELES CTY WOMEN & CHILDRENS HOSP,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,LOS ANGELES,CA