Luteal support with both estradiol and progesterone after clomiphene citrate stimulation for in vitro fertilization

被引:10
作者
Hurd, WW [1 ]
Randolph, JF [1 ]
Christman, GM [1 ]
Ansbacher, R [1 ]
Menge, AC [1 ]
Gell, JS [1 ]
机构
[1] UNIV MICHIGAN,DEPT OBSTET & GYNECOL,DIV REPROD ENDOCRINOL,ANN ARBOR,MI 48109
关键词
in vitro fertilization; luteal support; infertility; estradiol; progesterone; pregnancy;
D O I
10.1016/S0015-0282(16)58572-0
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To determine if pregnancy rates (PRs) for clomiphene citrate (CC)-stimulated TVF-ET can be increased by luteal support with E(2) and P. Design: Prospective randomized crossover clinical study. Setting: Infertile women volunteers in an academic research environment. Patients: Ninety-three infertile women underwent a total of 143 TVF-ET cycles using CC for ovulation induction. Interventions: Each woman received either no luteal support (control group) or luteal support with both oral E(2) (2 mg three times daily) starting on the day of retrieval and vaginal P suppositories (100 mg twice daily) starting on the day of ET. Main Outcome Measure: Clinical PR. Results: In 79 of 143 (55%) of the cycles, at least one embryo was transferred. Compared with the control group (n = 35 cycles), the luteal support group (n = 44 cycles) had a significantly higher PR per retrieval (control: 2% versus luteal support: 16%) and were older (control: 33 +/- 4 versus luteal support: 35 +/- 4 years; mean +/- SEM). They did not differ in terms of E(2) or P levels, endometrial thickness on the day of hCG, number of follicles > 16 mm in diameter, mature oocytes retrieved, or embryos transferred. Conclusions: Luteal support with both E(2) and P significantly increases the clinical PRs for CC-stimulated IVF-ET.
引用
收藏
页码:587 / 592
页数:6
相关论文
共 16 条
  • [1] CLOMIPHENES EFFECT ON ENDOMETRIUM IN INFERTILITY
    BENDA, JA
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 1992, 11 (04) : 273 - 282
  • [2] BENNUN I, 1992, FERTIL STERIL, V57, P953
  • [3] BONNBERG L, 1985, ANN NY ACAD SCI, V442, P408
  • [4] THE ECONOMIC-IMPACT OF MULTIPLE-GESTATION PREGNANCIES AND THE CONTRIBUTION OF ASSISTED-REPRODUCTION TECHNIQUES TO THEIR INCIDENCE
    CALLAHAN, TL
    HALL, JE
    ETTNER, SL
    CHRISTIANSEN, CL
    GREENE, MF
    CROWLEY, WF
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (04) : 244 - 249
  • [5] GARCIA J, 1981, FERTIL STERIL, V36, P565
  • [6] KETTEL LM, 1993, FERTIL STERIL, V59, P532
  • [7] MACDOUGALL MJ, 1994, FERTIL STERIL, V61, P1052
  • [8] MINIMAL STIMULATION WITH SIMPLIFIED MONITORING FOR IN-VITRO FERTILIZATION
    MASSEY, JB
    INGARGIOLA, PE
    TUCKER, MJ
    MITCHELLLEEF, DE
    WRIGHT, G
    [J]. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 1994, 11 (07) : 353 - 358
  • [9] PREDICTIVE VALUE OF SERUM ESTRADIOL CONCENTRATIONS AND OOCYTE NUMBER IN SEVERE OVARIAN HYPERSTIMULATION SYNDROME
    MORRIS, RS
    PAULSON, RJ
    SAUER, MV
    LOBO, RA
    [J]. HUMAN REPRODUCTION, 1995, 10 (04) : 811 - 814
  • [10] HORMONAL MANIPULATION OF ENDOMETRIAL MATURATION
    NAVOT, D
    ANDERSON, TL
    DROESCH, K
    SCOTT, RT
    KREINER, D
    ROSENWAKS, Z
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 68 (04) : 801 - 807