Synthesis of a first thiophene containing analog of the HIV protease inhibitor nelfinavir

被引：13

作者：

Bonini, C ^{[1
]}

Chiummiento, L ^{[1
]}

De Bonis, M ^{[1
]}

Funicello, M ^{[1
]}

Lupattelli, P ^{[1
]}

机构：

[1] Univ Basilicata, Dipartimento Chim, I-85100 Potenza, Italy

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 13期

关键词：

HIV-Pr inhibitors; peptidomimetics; hydroxyethylamine (HEA) inhibitors; nelfinavir analog; thiophene; sulfite;

D O I：

10.1016/j.tetlet.2004.02.026

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective and efficient preparation of a thiophene containing intermediate 2 from ethyl 3-thienyl propenoate 4 as the core of new possible HIV protease inhibitors is described. The chiral intermediate has been successfully used for the preparation of the analog I of the potent HIV inhibitor nelfinavir. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2797 / 2799

页数：3

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