Synthesis of novel Gn-RH analogues using Ugi-4MCR

被引：21

作者：

Arabanian, Armin ^{[1
]}

Mohammadnejad, Mahdieh ^{[1
]}

Balalaie, Saeed ^{[1
]}

Gross, Juergen H. ^{[2
]}

机构：

[1] KN Toosi Univ Technol, Peptide Chem Res Grp, Tehran, Iran

[2] Heidelberg Univ, Inst Organ Chem, D-69120 Heidelberg, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 03期

关键词：

Gn-RH analogues; 4-MCR Ugi reaction; Triptorelin and gonadorelin analogues; Ligation; GONADOTROPIN-RELEASING-HORMONE; PEPTIDE; LIGATION;

D O I：

10.1016/j.bmcl.2008.11.111

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An efficient method for the synthesis of some Gn-RH analogues based on Ugi reaction has been developed. Four-component reaction of N- and C-terminus peptides, aromatic aldehydes and isocyanides affords novel Gn-RH analogues derived from triptorelin and gonadorelin. All of the products were purified using preparative HPLC and the structures were assigned according to MALDI-mass spectrometry data. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.

引用

页码：887 / 890

页数：4

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