The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer

被引：72

作者：

Matsuo, Keitaro ^{[1
,2
]}

Oze, Isao ^{[1
]}

Hosono, Satoyo ^{[1
]}

Ito, Hidemi ^{[1
]}

Watanabe, Miki ^{[1
]}

Ishioka, Kuka ^{[1
,3
]}

Ito, Seiji ^{[4
]}

Tajika, Masahiro ^{[5
]}

Yatabe, Yasushi ^{[6
]}

Niwa, Yasumasa ^{[5
]}

Yamao, Kenji ^{[7
]}

Nakamura, Shigeo ^{[3
]}

Tajima, Kazuo ^{[8
]}

Tanaka, Hideo ^{[1
,2
]}

机构：

[1] Aichi Canc Ctr Res Inst, Div Epidemiol & Prevent, Nagoya, Aichi 4648681, Japan

[2] Nagoya Univ, Grad Sch Med, Dept Epidemiol, Nagoya, Aichi 4648550, Japan

[3] Nagoya Univ, Grad Sch Med, Dept Clin Pathophysiol & Clin Pathol, Nagoya, Aichi 4648550, Japan

[4] Aichi Canc Ctr Hosp, Dept Gastroenterol Surg, Nagoya, Aichi 4648681, Japan

[5] Aichi Canc Ctr Hosp, Dept Endoscopy, Nagoya, Aichi 4648681, Japan

[6] Aichi Canc Ctr Hosp, Dept Pathol & Mol Diagnost, Nagoya, Aichi 4648681, Japan

[7] Aichi Canc Ctr Hosp, Dept Gastroenterol, Nagoya, Aichi 4648681, Japan

[8] Aichi Canc Ctr Res Inst, Nagoya, Aichi 4648681, Japan

来源：

CARCINOGENESIS | 2013年 / 34卷 / 07期

基金：

日本学术振兴会;

关键词：

FOOD FREQUENCY QUESTIONNAIRE; CHRONIC ATROPHIC GASTRITIS; HELICOBACTER-PYLORI; GENETIC POLYMORPHISMS; JAPANESE MEN; CONSUMPTION; ESOPHAGEAL; METAANALYSIS; ASSOCIATION; POPULATION;

D O I：

10.1093/carcin/bgt080

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The impact of alcohol on the risk of stomach cancer is controversial. Although aldehyde dehydrogenase 2 (ALDH2) Glu504Lys (rs671) polymorphism has a strong effect on acetaldehyde metabolism, little is known about its impact on stomach cancer risk when combined with alcohol drinking. This case-control study included a total of 697 incident stomach cancer case subjects and 1372 non-cancer control subjects who visited Aichi Cancer Center between 2001 and 2005. We estimated odds ratios (OR) and 95% confidence intervals (CI) for ALDH2 genotypes and alcohol consumption using logistic regression models after adjustment for potential confounders, including Helicobacter pylori infection. The ALDH2 504Lys allele was associated with the risk of stomach cancer, with adjusted ORs of 1.40 (95% CI, 1.111.76) for Glu/Lys and 1.73 (1.122.68) for Lys/Lys compared with Glu/Glu. Heavy drinking was associated with risk (OR 1.72, 1.172.52) after adjustment for ALDH2 genotype and other confounders. Moreover, ORs for heavy drinking were 1.28 (0.772.12) for those with ALDH2 Glu/Glu and 3.93 (1.995.79) for those with the ALDH2 Lys allele relative to non-drinkers with the Glu/Glu genotype (P for interaction 0.0054). In conclusion, ALDH2 and alcohol drinking showed interaction for risk factors of stomach cancer, indicating that acetaldehyde plays a role in stomach carcinogenesis.

引用

页码：1510 / 1515

页数：6

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