Risk Factors for Severe Erectile Dysfunction after Focal Therapy with High-Intensity Focused Ultrasound for Prostate Cancer

被引:4
|
作者
Shoji, Sunao [1 ]
Kuroda, Satoshi [1 ]
Uemura, Kohei [2 ]
Oda, Kazuya [1 ]
Kano, Tatsuo [1 ]
Ogawa, Takahiro [1 ]
Umemoto, Tatsuya [1 ]
Nakano, Mayura [1 ]
Kawakami, Masayoshi [1 ]
Nitta, Masahiro [1 ]
Hasegawa, Masanori [1 ]
Miyajima, Akira [1 ]
机构
[1] Tokai Univ, Dept Urol, Sch Med, 143 Shimokasuya, Isehara, Kanagawa 2591143, Japan
[2] Univ Tokyo, Biostat & Bioinformat Course, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138654, Japan
关键词
sexual function; localized prostate cancer; focal therapy; high-intensity focused ultrasound; treated area; ABLATION; INDEX;
D O I
10.3390/biomedicines10112876
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The present study aimed to analyze the effect of predisposing clinical factors for severe erectile dysfunction (ED) in patients treated with focal therapy using high-intensity focused ultrasound (HIFU) for localized prostate cancer (PC). Patients without severe ED (International Index of Erectile Function-5 [IIEF-5] score >= 8) before focal HIFU therapy were included. A total of 92 of the 240 patients met the inclusion criteria and were included. The rate of severe ED (IIEF-5 <= 7) was 36% 12 months after treatment. Multivariable logistic regression analysis showed that the pre-procedural lower IIEF-5 score (odds ratio [OR] 0.812, p = 0.005), the pre-procedural lower score of the sexual domain of the Expanded Prostate Cancer Index Composite (OR 0.960, p = 0.038), and the treatment of the edge of the peripheral zone (PZ) in proximity to the neurovascular bundle (NVB) [treated vs. untreated, OR 8.048, p = 0.028] were significant risk factors for severe ED at 12 months after treatment. In conclusion, pre-procedural lower erectile function and treatment of the part in proximity to the NVB were significant risk factors for severe ED after focal therapy.
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页数:9
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