The Comparative Effects of Valsartan and Amlodipine on Vascular Microinflammation in Newly Diagnosed Hypertensive Patients

被引：37

作者：

Unlu, Murat ^{[1
]}

Karaman, Murat ^{[2
]}

Ay, Seyit Ahmet ^{[2
]}

Balta, Sevket ^{[3
]}

Cakar, Mustafa ^{[2
]}

Demirkol, Sait ^{[3
]}

Celik, Turgay ^{[3
]}

Arslan, Erol ^{[2
]}

Demirbas, Seref ^{[2
]}

Turker, Turker ^{[4
]}

Yaman, Halil ^{[5
]}

Bulucu, Fatih ^{[2
]}

Saglam, Kenan ^{[2
]}

机构：

[1] Beytepe Hosp, Dept Cardiol, Ankara, Turkey

[2] Gulhane Mil Med Acad, Dept Internal Med, Ankara, Turkey

[3] Gulhane Mil Med Acad, Dept Cardiol, Ankara, Turkey

[4] Gulhane Mil Med Acad, Dept Publ Hlth, Ankara, Turkey

[5] Gulhane Mil Med Acad, Dept Med Biochem, Ankara, Turkey

来源：

CLINICAL AND EXPERIMENTAL HYPERTENSION | 2013年 / 35卷 / 06期

关键词：

pentraxin; C-reactive protein; inflammation; amlodipine; valsartan; hypertension; C-REACTIVE PROTEIN; LONG PENTRAXIN PTX3; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; RENAL-FUNCTION; INFLAMMATION; ATHEROSCLEROSIS; RECOGNITION; REGRESSION; STRESS;

D O I：

10.3109/10641963.2012.739237

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pentraxin 3 (PTX3) is a new candidate immunoinflammatory marker that has been reported to be associated with cardiometabolic risk factors. We aimed to investigate the effects of valsartan and amlodipine on the PTX3 and C-reactive protein (CRP) levels in patients with essential hypertension. Patients with a newly diagnosed essential hypertension were admitted to our internal medicine outpatient clinic. Patients were randomized to one of the following intervention protocols: calcium channel blocker (amlodipine, 5-10 mg/day) as group A (n = 22; mean age +/- standard deviation [SD]: 52 +/- 11 year) and angiotensine II receptor blocker (valsartan, 80-320 mg/day) as group B (n = 28; mean age +/- SD: 50 +/- 14 year). Endothelial dysfunction and systemic inflammation were evaluated with PTX3 and CRP. There was a significant decrease in the level of PTX3 after treatment in two groups (P < .05). Although there was a significant decrease in the level of CRP after treatment in amlodipine group, there was no significant decrease in the levels of PTX3 and CRP after treatment in two groups. There were no significant differences in the systolic and diastolic blood pressure reduction between the two treatment groups. In the treatment of hypertension, prior knowledge of the level of plasma PTX3 could be important in antihypertensive drug choice. C-reactive protein and PTX3 are the markers that have role in vascular inflammation and are found associated with the prognosis of cardiovascular outcomes in many trials. In our study, PTX and CRP levels were decreased when compared to baseline levels.

引用

页码：418 / 423

页数：6

共 32 条

[31] Impact of amlodipine or ramipril treatment on left ventricular mass and carotid intima-media thickness in nondiabetic hemodialysis patients [J].