Thioredoxin suppresses 1-methyl-4-phenylpyridinium-induced neurotoxicity in rat PC12 cells

被引：70

作者：

Bai, J ^{[1
]}

Nakamura, H ^{[1
]}

Hattori, I ^{[1
]}

Tanito, M ^{[1
]}

Yodoi, J ^{[1
]}

机构：

[1] Kyoto Univ, Inst Virus Res, Dept Biol Responses, Kyoto 6068507, Japan

来源：

NEUROSCIENCE LETTERS | 2002年 / 321卷 / 1-2期

基金：

日本学术振兴会;

关键词：

thioredoxin; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; geranylgeranylacetone; Parkinson disease; PC12; cells;

D O I：

10.1016/S0304-3940(02)00058-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Thioredoxin (TRX) is a redox-active protein which plays a cytoprotective role against oxidative stress. Geranylgeranylacetone (GGA), used widely as an anti-ulcer drug, has been reported to induce TRX as well as heat shock protein 70 (HSP70) in hepatocytes and other cells. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), causes dopaminergic denervation and Parkinsonism in humans. The 1-methyl-4-phenylpyridinium ion (MPP+), an active metabolite of MPTP, induces cell death in a rat pheochromocytoma cell line (PC12 cells). We found that MPP+ suppresses TRX expression in PC12 cells. Overexpression or administration of TRX attenuates MPP+-induced neurotoxicity on PC12 cells. Moreover, GGA induces expression of TRX and HSP70 and attenuates MPP+-induced toxicity in PC12 cells. These results indicate that TRX and GGA have a possible potential as new therapeutic agents for Parkinson disease. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：81 / 84

页数：4

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