Mass spectrometry MALDI imaging of colon cancer biomarkers: a new diagnostic paradigm

被引：23
|
作者：
Pevsner, Paul H. [1 ]
Melamed, Jonathan [2 ]
Remsen, Tiffany [1 ]
Kogos, Alexander [1 ]
Francois, Fritz [3 ]
Kessler, Paul [1 ]
Stern, Arnold [1 ]
Anand, Sury [4 ]
机构：
[1] NYU, Sch Med, Dept Pharmacol, New York, NY 10003 USA
[2] NYU, Sch Med, Dept Pathol, New York, NY USA
[3] NYU, Sch Med, Dept Med, Div Gastroenterol, New York, NY USA
[4] Brooklyn Hosp Ctr, Div Gastroenterol, Dept Pharmacol, Brooklyn, NY USA
来源：
BIOMARKERS IN MEDICINE | 2009年 / 3卷 / 01期
关键词：
biomarker; colorectal cancer; imaging; LCMS; liquid chromatography mass spectrometry; MALDI IMS; mass spectrometry; matrix-assisted laser desorption/ionization imaging mass spectrometry; HUMAN CHORIONIC-GONADOTROPIN; DIRECT TISSUE-ANALYSIS; COLORECTAL-CANCER; APOPTOSIS; PROTEINS; MUCOSA; EXPRESSION; CELLS; MS; IDENTIFICATION;
D O I：
10.2217/17520363.3.1.55
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Colorectal cancer (CRC), is the second-leading cause of cancer-related deaths in the USA, affecting both men and women. Current projections show little or no change since the publication of a morbidity and mortality study in 2005. The projected number of new cases for 2008 is 154,000, and the projected number of CRC cancer deaths for 2008 is 53,000. The standard diagnostic paradigm is based on histopathology of either biopsy or surgical specimens. This article suggests a new paradigm for colon cancer diagnosis and staging using matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS or IMS). IMS may identify potential tumors in normal tissue of cancer patients and predict those cancer patients who are at risk for recurrent cancer.
引用
收藏
页码：55 / 69
页数：15
相关论文
共 50 条
  • [1] MALDI imaging mass spectrometry in ovarian cancer for tracking, identifying, and validating biomarkers
    El Ayed, Mohamed
    Bonnel, David
    Longuespee, Remi
    Castellier, Celine
    Franck, Julien
    Vergara, Daniele
    Desmons, Annie
    Tasiemski, Aurelie
    Kenani, Abderraouf
    Vinatier, Denis
    Day, Robert
    Fournier, Isabelle
    Salzet, Michel
    MEDICAL SCIENCE MONITOR, 2010, 16 (08): : BR233 - BR245
  • [2] MALDI imaging mass spectrometry: an emerging tool in neurology
    Schnackenberg, Laura K.
    Thorn, David A.
    Barnette, Dustyn
    Jones, E. Ellen
    METABOLIC BRAIN DISEASE, 2022, 37 (01) : 105 - 121
  • [3] MALDI Imaging Mass Spectrometry
    Franck, Julien
    Arafah, Karim
    Elayed, Mohamed
    Bonnel, David
    Vergara, Daniele
    Jacquet, Amelie
    Vinatier, Denis
    Wisztorski, Maxence
    Day, Robert
    Fournier, Isabelle
    Salzet, Michel
    MOLECULAR & CELLULAR PROTEOMICS, 2009, 8 (09) : 2023 - 2033
  • [4] A new panel of pancreatic cancer biomarkers discovered using a mass spectrometry-based pipeline
    Liu, Xiaohui
    Zheng, Weimin
    Wang, Wansheng
    Shen, Huali
    Liu, Linxiao
    Lou, Wenhui
    Wang, Xiaolin
    Yang, Pengyuan
    BRITISH JOURNAL OF CANCER, 2017, 117 (12) : 1846 - 1854
  • [5] Molecular Morphology of the Chick Heart Visualized by MALDI Imaging Mass Spectrometry
    Grey, Angus C.
    Gelasco, Andrew K.
    Section, Jarren
    Moreno-Rodriguez, Ricardo A.
    Krug, Edward L.
    Schey, Kevin L.
    ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 2010, 293 (05): : 821 - 828
  • [6] Peptide and protein imaging mass spectrometry in cancer research
    McDonnell, Liam A.
    Corthals, Garry L.
    Willems, Stefan M.
    van Remoortere, Alexandra
    van Zeijl, Rene J. M.
    Deelder, Andre M.
    JOURNAL OF PROTEOMICS, 2010, 73 (10) : 1921 - 1944
  • [7] MALDI Imaging Mass Spectrometry (MALDI-IMS)-Application of Spatial Proteomics for Ovarian Cancer Classification and Diagnosis
    Gustafsson, Johan O. R.
    Oehler, Martin K.
    Ruszkiewicz, Andrew
    McColl, Shaun R.
    Hoffmann, Peter
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2011, 12 (01) : 773 - 794
  • [8] New developments in profiling and imaging of proteins from tissue sections by MALDI mass spectrometry
    Chaurand, Pierre
    Norris, Jeremy L.
    Cornett, D. Shannon
    Mobley, James A.
    Caprioli, Richard M.
    JOURNAL OF PROTEOME RESEARCH, 2006, 5 (11) : 2889 - 2900
  • [9] Localization and imaging of sialylated glycosphingolipids in brain tissue sections by MALDI mass spectrometry
    Colsch, Benoit
    Woods, Amina S.
    GLYCOBIOLOGY, 2010, 20 (06) : 661 - 667
  • [10] The Characterization of Laser Ablation Patterns and a New Definition of Resolution in Matrix Assisted Laser Desorption Ionization Imaging Mass Spectrometry (MALDI-IMS)
    O'Rourke, Matthew B.
    Raymond, Benjamin B. A.
    Padula, Matthew P.
    JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2017, 28 (05) : 895 - 900
12345