Purinoceptor-mediated, Capsaicin-resistant Excitatory Effect of Allyl Isothiocyanate on Neurons of the Guinea-Pig Small Intestine

被引：9

作者：

Bartho, Lorand ^{[1
]}

Nordtveit, Elin ^{[1
]}

Szombati, Veronika ^{[1
]}

Benko, Rita ^{[1
]}

机构：

[1] Univ Med Sch Pecs, Dept Pharmacol & Pharmacotherapy, H-7643 Pecs, Hungary

来源：

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY | 2013年 / 113卷 / 02期

关键词：

GASTROINTESTINAL MOTILITY; TRPA1; TRPV1; MICE;

D O I：

10.1111/bcpt.12060

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Allyl isothiocyanate (AITC; 200 mu M) caused atropine-and tetrodotoxin-sensitive longitudinal muscle contraction on the guinea-pig small intestine. The response was not influenced by hexamethonium, a functional blockade of capsaicin-sensitive neurons or by antagonists acting at TRPV1 or TRPA1, but was abolished by the P-2 purinoceptor antagonist PPADS (50 mu M). It is concluded that cholinergic motoneurons are activated by a purinergic mechanism in the course of the AITC response, independently of capsaicin-sensitive processes or even TRPA1.

引用

页码：141 / 143

页数：3

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