Sphingosine-1-phosphate receptor 2

被引：107

作者：

Adada, Mohamad ^{[1
]}

Canals, Daniel ^{[1
]}

Hannun, Yusuf A. ^{[1
]}

Obeid, Lina M. ^{[1
,2
]}

机构：

[1] SUNY Stony Brook, Dept Med, Stony Brook, NY 11794 USA

[2] Northport VA Med Ctr, Northport, NY USA

来源：

FEBS JOURNAL | 2013年 / 280卷 / 24期

基金：

美国国家卫生研究院;

关键词：

cancer; ceramide; ezrin; JTE013; S1P knockout mouse; S1PR2; SID46371153; sphingolipid diseases; sphingolipids; sphingosine; 1-phosphate; SPHINGOSINE 1-PHOSPHATE RECEPTOR; PROTEIN-COUPLED RECEPTOR; CELL-PROLIFERATION; LYMPHOCYTE EGRESS; MOLECULAR-CLONING; SMOOTH-MUSCLE; MICE LACKING; ACTIVATION; MIGRATION; INHIBITION;

D O I：

10.1111/febs.12446

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sphingosine-1-phosphate (S1P) is a potent bioactive sphingolipid involved in cell proliferation, angiogenesis, inflammation and malignant transformation among other functions. S1P acts either directly on intracellular targets or activates G protein-coupled receptors, specifically five S1P receptors (S1PRs). The identified S1PRs differ in cellular and tissue distribution, and each is coupled to specific Gproteins, which mediate unique functions. Here, we describe functional characteristics of all five receptors, emphasizing S1PR2, which is critical in the immune, nervous, metabolic, cardiovascular, musculoskeletal, and renal systems. This review also describes the role of this receptor in tumor growth and metastasis and suggests potential therapeutic avenues that exploit S1PR2.

引用

页码：6354 / 6366

页数：13

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