Ninety-Day Subchronic Oral Toxicity Study of Senecio scandens Extract in Rats

被引:1
作者
Wang, Xiu-Kun [1 ,2 ,3 ]
Zhao, Yong [1 ]
Liu, Ting [1 ]
Yi, Yan [1 ]
Li, Chun-Ying [1 ]
Wang, Hong-Jie [1 ]
Wang, Chang-Hong [4 ]
Wang, Zheng-Tao [4 ]
Ye, Zu-Guang [1 ]
Lane, Ai-Hua [1 ]
机构
[1] China Acad Tradit Chinese Med, Inst Chinese Mat Med, Beijing 100700, Peoples R China
[2] Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China
[3] Chinese Acad Med Sci, Beijing 100050, Peoples R China
[4] Shanghai Univ Tradit Chinese Med, Minist Educ, Key Lab Standardizat Chinese Med, Shanghai 201203, Peoples R China
基金
国家教育部博士点专项基金资助;
关键词
Senecio scandens; subchronic toxicity; rat; safety; HEPATIC VENOOCCLUSIVE DISEASE; PYRROLIZIDINE ALKALOIDS; QUANTITATIVE-ANALYSIS; MEDICINAL-PLANTS; ASTERACEAE; QIANLIGUANG; DIVERSITY; HERB; TEA;
D O I
10.1248/bpb.b15-00316
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The present study assessed the safety/toxicity of Senecio scandens, a well-known Chinese herb that is used as an anti-inflammatory, antibiosis, and antipyretic drug. A 90-d subchronic oral toxicity study of S. scandens was performed in Wistar rats. The extract of S. scandens was administered orally to male and female rats at a single dose of 225, 450, and 900 mg/kg/d. There was no obvious toxicity. Certain changes in hematology and coagulation parameters (red cell distribution width (RDW), platelet count (PLT), monocyte percentage (Mo%), activated partial thromboplastin time (APTT), prothrombin time (PT)) were observed in some administration groups. In regards to the blood biochemical parameters, the levels of creatinine (CRN), potassium, and chloride were increased in a number of the treated rats. There were no significant changes in other hematology, coagulation, or biochemical parameters in rats orally administered S. scandens. S. scandens has a slight effect on rat coagulation and metabolism systems. The herb was safe at all doses tested, but caution should be taken when administering S. scandens at higher doses.
引用
收藏
页码:1548 / 1556
页数:9
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