Transmission of Metabolic Dysfunction Across Generations

被引：16
|
作者：
Jaeger, Kathleen [1 ]
Saben, Jessica L. [1 ]
Moley, Kelle H. [1 ]
机构：
[1] Washington Univ, Sch Med, St Louis, MO 63130 USA
来源：
PHYSIOLOGY | 2017年 / 32卷 / 01期
关键词：
EPIGENETIC TRANSGENERATIONAL INHERITANCE; HIGH-FAT DIET; GESTATIONAL DIABETES-MELLITUS; BODY-MASS INDEX; DNA METHYLATION; MESSENGER-RNAS; ADIPOSE-TISSUE; MITOCHONDRIAL DYSFUNCTION; PRENATAL EXPOSURE; OOCYTE QUALITY;
D O I：
10.1152/physiol.00017.2016
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Recent human and animal studies investigating the roles of the genome, epigenome, and environmental cues have identified associations between offspring predisposition to life-long obesity/metabolic disease and epigenetic modifications such as DNA methylation. This review explores the mechanisms by which maternal exposures impair the health of not only the next generation but also potentially future generations of offspring.
引用
收藏
页码：51 / 59
页数：9
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