Benzenesulfonamide peptide conjugates as probes for secondary binding sites near the active site of carbonic anhydrase

被引：17

作者：

Sigal, GB ^{[1
]}

Whitesides, GM ^{[1
]}

机构：

[1] HARVARD UNIV, DEPT CHEM, CAMBRIDGE, MA 02138 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0960-894X(96)00069-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Libraries of N-(4-sulfamoylbenzoyl)oligoglycines terminated with different L-amino acids were screened to identify tight binding inhibitors of human carbonic anhydrase II. Inhibitors terminated with hydrophobic amino acids showed significant enhancements in binding compared to the corresponding glycine derivatives. No enhancements were observed due to polar interactions.

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页码：559 / 564

页数：6

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