DRD2/ANKK1 Taq1A polymorphism (rs1800497) has opposing effects on D2/3 receptor binding in healthy controls and patients with major depressive disorder

被引：45

作者：

Savitz, Jonathan ' ^{[1
,2
,3
]}

Hodgkinson, Colin A. ^{[4
]}

Martin-Soelch, Chantal ^{[5
]}

Shen, Pei-Hong ^{[4
]}

Szczepanik, Joanna ^{[3
]}

Nugent, Allison C. ^{[6
]}

Herscovitch, Peter ^{[7
]}

Grace, Anthony A. ^{[8
,9
,10
]}

Goldman, David ^{[4
]}

Drevets, Wayne C. ^{[1
,3
,11
]}

机构：

[1] Laureate Inst Brain Res, Tulsa, OK 74136 USA

[2] Univ Tulsa, Fac Community Med, Tulsa, OK 74104 USA

[3] NIMH, Sect Neuroimaging Mood & Anxiety Disorders, Mood & Anxiety Disorders Program, NIH, Bethesda, MD 20892 USA

[4] NIAAA, Neurogenet Lab, NIH, Rockville, MD 20852 USA

[5] Univ Zurich Hosp, Dept Psychiat & Psychotherapy, Zurich, Switzerland

[6] NIMH, NIH, Bethesda, MD 20892 USA

[7] NIH, Ctr Clin, Bethesda, MD 20892 USA

[8] Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15260 USA

[9] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA

[10] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA

[11] Johnson & Johnson Pharmaceut Res & Dev, Titusville, NJ USA

来源：

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2013年 / 16卷 / 09期

关键词：

Depression; dopamine; 2; receptor; positron emission tomography; reward; Taq1A; AVAILABILITY IN-VIVO; A1; ALLELE; C957T POLYMORPHISM; DRD2; GENE; DOPAMINE; VOLUNTEERS; STRIATUM; STRESS; SYSTEM; BRAIN;

D O I：

10.1017/S146114571300045X

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The A1 allele of the DRD2/ANKK1 Taq1A polymorphism (rs1800497) is associated with reduced striatal D-2/3 receptor binding in healthy individuals (Con) as well as depression and addiction. However, the effect of rs1800497 on D-2/3 receptor binding in depressed patients as well as the SNP's effect on D-2/3 binding during reward-associated dopamine release is unknown. Twelve unmedicated patients with major depressive disorder (MDD) and 24 Con completed PET scans with [C-11]raclopride, once without receiving monetary rewards (baseline) and once while winning money. In Con, the A1 allele was associated with reduced baseline binding potential (BPND) in the middle caudate and ventral striatum. However, in MDD patients the A1 allele was associated with increased baseline BPND in these regions. There were no significant associations between rs1800497 and change in BPND during reward-associated dopamine release. Conceivably, the A1 allele predisposes to depression and addiction via its effect on the post-synaptic D-2 receptor.

引用

页码：2095 / 2101

页数：7

共 40 条

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