Combined EGFR/ALK Expression Analysis in Laryngeal Squamous Cell Carcinoma

被引：8

作者：

Politi, Anastasia ^{[1
]}

Tsiamb, Evangelos ^{[2
]}

Mastronikolis, Nicholas S. ^{[3
]}

Peschos, Dimitrios ^{[4
]}

Asproudis, Ioannis ^{[5
]}

Kyrodimos, Efthymios ^{[6
]}

Armata, Ilianna E. ^{[7
]}

Chrysovergis, Aristeidis ^{[6
]}

Asimakopoulos, Asimakis ^{[8
]}

Papanikolaou, Vasileios S. ^{[6
]}

Batistatou, Anna ^{[9
]}

Ragos, Vasileios ^{[10
]}

机构：

[1] Univ Ioannina, Med Sch, Dept Oncol, Ioannina, Greece

[2] 401 GAH, Dept IHC & Mol Biol, Athens, Greece

[3] Univ Patras, Med Sch, ENT Dept, Patras, Greece

[4] Univ Ioannina, Med Sch, Dept Physiol, Ioannina, Greece

[5] Univ Ioannina, Med Sch, Dept Ophthalmol, Ioannina, Greece

[6] Natl & Kapodistrian Univ Athens, Hippokrat Hosp, IST ENT Dept, Athens, Greece

[7] Cambridge Univ Hosp, Med Sch, Cambridge, England

[8] Luxembourg Hosp Ctr, ENT Dept, Luxembourg, Luxembourg

[9] Univ Ioannina, Med Sch, Dept Pathol, Ioannina, Greece

[10] Univ Ioannina, Med Sch, Dept Maxillofacial, Ioannina, Greece

来源：

IN VIVO | 2019年 / 33卷 / 03期

关键词：

Carcinoma; larynx; EGFR; ALK; GROWTH-FACTOR RECEPTOR; CANCER; ALK; NECK; HEAD; MET; SURVIVAL; GENE;

D O I：

10.21873/invivo.11544

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: Epidermal growth factor receptor (EGFR) acts as an oncogene in malignancies. Our aim was to examine the role of combined EGFR/ anaplastic lymphoma kinase (ALK) expression as molecular markers in laryngeal squamous cell carcinoma (LSCC) patients. Materials and Methods: Fifty (n=50) tissue sections derived from twenty-five (n=25) primary LSCCs were analyzed by immunohistochemistry (IHC). Results: EGFR overexpression was observed in 17/25 (68%) cases. Concerning ALK, 23/25 (92%) demonstrated low expression. EGFR expression was associated with grade (p=0.049), whereas ALK expression was correlated with stage (p=0.048). ALK overexpression was detected at advanced-stage EGFR-positive cases. A biphasic EGFR protein expression pattern was observed in five (n=5) LSCC cases, whereas ALK expression was stable in all cases. Conclusion: EGFR overexpression is frequently observed in LSCC combined with low ALK expression. LSCC patients with EGFR/ALK protein overexpression should be eligible for targeted therapeutic strategies.

引用

页码：815 / 819

页数：5

共 27 条

[1] Ang KK, 2002, CANCER RES, V62, P7350
[2] Arteaga CL, 2001, J CLIN ONCOL, V19, p32S
[3] Barnes L, 2005, PATHOLOGY GENETICS H, P118
[4] Mutation analysis of genes in the EGFR pathway in Head and Neck cancer patients: Implications for anti-EGFR treatment response
Boeckx C.
Weyn C.
Vanden Bempt I.
Deschoolmeester V.
Wouters A.
Specenier P.
Van Laer C.
Van Den Weyngaert D.
Kockx M.
Vermorken J.B.
Peeters M.
Pauwels P.
Lardon F.
Baay M.
[J]. BMC Research Notes, 7 (1)
[5] Cytoplasmic EGFR Staining and Gene Amplification in Glottic Cancer: A Better Indicator of EGFR-driven Signaling?
Braut, Tamara
Krstulja, Mira
Rukavina, Koraljka M.
Jonjic, Nives
Kujundzic, Milodar
Manestar, Ines D.
Katunaric, Miljenko
Manestar, Darko
[J]. APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2014, 22 (09) : 674 - 680
[6] Co-targeting ALK and EGFR parallel signaling in oral squamous cell carcinoma
Gonzales, Cara B.
De La Chapa, Jorge J.
Saikumar, Pothana
Singha, Prajjal K.
Dybdal-Hargreaves, Nicholas F.
Chavez, Jeffery
Horning, Aaron M.
Parra, Jamie
Kirma, Nameer B.
[J]. ORAL ONCOLOGY, 2016, 59 : 12 - 19
[7] Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system
Iwahara, T
Fujimoto, J
Wen, DZ
Cupples, R
Bucay, N
Arakawa, T
Mori, S
Ratzkin, B
Yamamoto, T
[J]. ONCOGENE, 1997, 14 (04) : 439 - 449
[8] High expression of c-Met and EGFR is associated with poor survival of patients with glottic laryngeal squamous cell carcinoma
Jiang, Mei
Zhang, Hui
Xiao, He
Zhang, Zhimin
Que, Dan
Luo, Jia
Li, Jian
Mao, Bijing
Chen, Yuanyuan
Lan, Meilin
Wang, Ge
Xiao, Hualiang
[J]. ONCOLOGY LETTERS, 2018, 15 (01) : 931 - 939
[9] Presence of anaplastic lymphoma kinase translocation in sarcomatoid carcinoma of head and neck and treatment effect of crizotinib: A case series
Kim, Sung Min
Kim, Moon Jin
Jung, Hyun Ae
Sun, Jong-Mu
Choi, Yoon-La
Ko, Young-Hyeh
Park, Keunchil
Baek, Chung-Hwan
Son, Young-Ik
Ahn, Myung-Ju
[J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2015, 37 (05): : E66 - E69
[10] Epidermal growth factor receptor (EGFR) expression in patients with laryngeal squamous cell carcinoma
Kontic, Mirko
Milovanovic, Jovica
Colovic, Zavisa
Poljak, Nikola Kolja
Sundov, Zeljko
Sucic, Ante
Pesutic-Pisac, Valdi
[J]. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2015, 272 (02) : 401 - 405

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