Dengue: A Minireview

被引：216

作者：

Harapan, Harapan ^{[1
,2
,3
,4
]}

Michie, Alice ^{[4
]}

Sasmono, R. Tedjo ^{[5
]}

Imrie, Allison ^{[4
]}

机构：

[1] Univ Syiah Kuala, Sch Med, Med Res Unit, Banda Aceh 23111, Aceh, Indonesia

[2] Univ Syiah Kuala, Sch Med, Dept Microbiol, Banda Aceh 23111, Aceh, Indonesia

[3] Univ Syiah Kuala, Sch Med, Trop Dis Ctr, Banda Aceh 23111, Aceh, Indonesia

[4] Univ Western Australia, Sch Biomed Sci, Nedlands, WA 6009, Australia

[5] Eijkman Inst Mol Biol, Jakarta 10430, Indonesia

来源：

VIRUSES-BASEL | 2020年 / 12卷 / 08期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

dengue; epidemiology; pathogenesis; diagnosis; treatment; disease control; ANTIBODY-DEPENDENT ENHANCEMENT; ORIGINAL ANTIGENIC SIN; FEVER/DENGUE HEMORRHAGIC-FEVER; FLAVIVIRUS-NAIVE ADULTS; NECROSIS-FACTOR-ALPHA; TYPE-1 DNA VACCINE; RISK-FACTORS; VIRUS-INFECTION; SHOCK SYNDROME; IMMUNE-RESPONSES;

D O I：

10.3390/v12080829

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Dengue, caused by infection of any of four dengue virus serotypes (DENV-1 to DENV-4), is a mosquito-borne disease of major public health concern associated with significant morbidity, mortality, and economic cost, particularly in developing countries. Dengue incidence has increased 30-fold in the last 50 years and over 50% of the world's population, in more than 100 countries, live in areas at risk of DENV infection. We reviews DENV biology, epidemiology, transmission dynamics including circulating serotypes and genotypes, the immune response, the pathogenesis of the disease as well as updated diagnostic methods, treatments, vector control and vaccine developments.

引用

页数：35

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