CRISPR/Cas9-mediated engineering of insulin-secreting cells to study Type 2 diabetes risk variants of the gene SLC30A8/ZnT8 the Zn2+transporter

被引:0
|
作者
Chabosseau, P. [1 ]
Cheung, R. [1 ]
Rutter, G. A. [1 ]
机构
[1] Imperial Coll, Dept Med, Sect Cell Biol & Funct Genom, London, England
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
P30
引用
收藏
页码:45 / 45
页数:1
相关论文
共 38 条
  • [1] SLC30A8 (ZnT8) variations and type 2 diabetes in the Chinese Han population
    Xu, J.
    Wang, J.
    Chen, B.
    GENETICS AND MOLECULAR RESEARCH, 2012, 11 (02) : 1592 - 1598
  • [2] Hypoxia alters the expression of the type 2 diabetes-associated Zn2+ transporter Slc30a8/ZnT8 and cytosolic Zn2+levels in human and rodent islets
    Gerber, P. A.
    Bellomo, E. A.
    Meur, G.
    Hodson, D. J.
    Solomou, A.
    Hollinshead, M.
    Chimienti, F.
    Lavallard, V. J.
    Bosco, D.
    Hughes, S. J.
    Johnson, P. R.
    Rutter, G. A.
    DIABETOLOGIA, 2013, 56 : S16 - S16
  • [3] Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells
    Philipp A. Gerber
    Elisa A. Bellomo
    David J. Hodson
    Gargi Meur
    Antonia Solomou
    Ryan K. Mitchell
    Michael Hollinshead
    Fabrice Chimienti
    Domenico Bosco
    Stephen J. Hughes
    Paul R. V. Johnson
    Guy A. Rutter
    Diabetologia, 2014, 57 : 1635 - 1644
  • [4] Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells
    Gerber, Philipp A.
    Bellomo, Elisa A.
    Hodson, David J.
    Meur, Gargi
    Solomou, Antonia
    Mitchell, Ryan K.
    Hollinshead, Michael
    Chimienti, Fabrice
    Bosco, Domenico
    Hughes, Stephen J.
    Johnson, Paul R. V.
    Rutter, Guy A.
    DIABETOLOGIA, 2014, 57 (08) : 1635 - 1644
  • [5] Zinc transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese
    Xiang, Jie
    Li, Xiao-Ying
    Xu, Min
    Hong, Jie
    Huang, Yun
    Tan, Jiao-Rong
    Lu, Xi
    Dai, Meng
    Yu, Bing
    Ning, Guang
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (10): : 4107 - 4112
  • [6] Zinc transporter 8 (SLC30A8), an insulin secretory granule protein with links to the pathogenesis of type 1 and type 2 diabetes
    Hutton, John C.
    Wenzlau, Janet M.
    O'Brien, Richard
    Gardner, Thomas
    Kawasaki, Eiji
    Zhou, Zhiguang
    Zeigler, Anette G.
    Sheridan, Leah
    Sarkar, Suparna
    Davidson, Howard W.
    ENDOCRINE JOURNAL, 2010, 57 : S220 - S220
  • [7] Protein truncating variants of SLC30A8 reduce type 2 diabetes mellitus risk in humans
    Yakala, G. K.
    CLINICAL GENETICS, 2014, 86 (02) : 121 - 122
  • [8] Impact of type 2 diabetes-associated variants at the SLC30A8 locus on transcriptional activity and function of human b cells and super-enhancer at SLC30A8 gene locus
    Hu, M.
    Kim, I.
    Canouil, M.
    Bonas-Guarch, S.
    Khamis, A. A.
    Ferrer, J.
    Froguel, P.
    Rutter, G. R.
    DIABETOLOGIA, 2022, 65 (SUPPL 1) : S141 - S141
  • [9] Contribution of SLC30A8 variants to the risk of type 2 diabetes in a multi-ethnic population: a case control study
    Sameer D Salem
    Riyadh Saif-Ali
    Ikram S Ismail
    Zaid Al-Hamodi
    Sekaran Muniandy
    BMC Endocrine Disorders, 14
  • [10] Contribution of SLC30A8 variants to the risk of type 2 diabetes in a multi-ethnic population: a case control study
    Salem, Sameer D.
    Saif-Ali, Riyadh
    Ismail, Ikram S.
    Al-Hamodi, Zaid
    Muniandy, Sekaran
    BMC ENDOCRINE DISORDERS, 2014, 14