Allogeneic Stem Cell Transplantation for Patients Age ≥ 70 Years with Myelodysplastic Syndrome: A Retrospective Study of the MDS Subcommittee of the Chronic Malignancies Working Party of the EBMT

被引：43

作者：

Heidenreich, Silke ^{[1
,25
]}

Ziagkos, Dimitris ^{[2
]}

de Wreede, Liesbeth C. ^{[2
,3
]}

van Biezen, Anja ^{[4
]}

Finke, Juergen ^{[5
]}

Platzbecker, Uwe ^{[6
]}

Niederwieser, Dietger ^{[7
]}

Einsele, Hermann ^{[8
]}

Bethge, Wolfgang ^{[9
]}

Schleuning, Michael ^{[10
]}

Beelen, Dietrich W. ^{[11
]}

Tischer, Johanna ^{[12
]}

Nagler, Arnon ^{[13
]}

Glass, Bertram ^{[14
]}

Maertens, Johan ^{[15
]}

Yanez, Lucrecia ^{[16
]}

Beguin, Yves ^{[17
]}

Sill, Heinz ^{[18
]}

Scheid, Christof ^{[19
]}

Stelljes, Matthias ^{[20
]}

Ganser, Arnold ^{[21
]}

Zachee, Pierre ^{[22
]}

Selleslag, Dominik ^{[23
]}

de Witte, Theo ^{[24
]}

Robin, Marie ^{[25
]}

Kroeger, Nicolaus ^{[1
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Dept Stem Cell Transplantat, Hamburg, Germany

[2] Leiden Univ, Dept Med Stat & Bioinformat, Med Ctr, NL-2300 RA Leiden, Netherlands

[3] German Bone Marrow Donor Ctr, DKMS, Tubingen, Germany

[4] Univ Med Ctr, EBMT Data Off, Leiden, Netherlands

[5] Univ Med Ctr Freiburg, Dept Med, Freiburg, Germany

[6] Tech Univ Dresden, Univ Klinikum Carl Gustav Carus, Med Klin & Poliklin 1, Dresden, Germany

[7] Univ Leipzig, Hematol & Oncol, Leipzig, Germany

[8] Univ Med Ctr, Dept Internal Med, Wurzburg, Germany

[9] Univ Tubingen, Med Ctr, Dept Internal Med 2, Tubingen, Germany

[10] DKD Helios Klin, Ctr Hematopoiet Cell Transplantat, Wiesbaden, Germany

[11] Univ Hosp Essen, Dept Bone Marrow Transplantat, West German Canc Ctr, Essen, Germany

[12] Ludwig Maximilians Univ Hosp Munich Grosshadern, Dept Internal Med 3, Hematopoiet Cell Transplantat, Munich, Germany

[13] Sheba Med Ctr, Div Hematol, Tel Hashomer, Israel

[14] Asklepios Hosp St Georg, Hematol Oncol & Stem Cell Transplantat, Hamburg, Germany

[15] Univ Hosp Gasthuisberg Leuven, Dept Hematol, Leuven, Belgium

[16] Univ Hosp Marques de Valdecilla, Dept Hematol, Santander, Spain

[17] Univ Liege, Hematol Lab, GIGA 13, CHU Sart Tilman, Liege, Belgium

[18] Med Univ Graz, Div Hematol, Graz, Austria

[19] Univ Cologne, Dept Med, Cologne, Germany

[20] Univ Munster, Dept Hematol Oncol, Munster, Germany

[21] Hannover Med Sch, Dept Hematol Hemostasis Oncol & Stem Cell Transpl, Hannover, Germany

[22] Ziekenhuisnetwerk Antwerpen, Dept Hematol, Antwerp, Belgium

[23] Acad Hosp St Jan, Dept Hematol, Brugge, Belgium

[24] Radboud Univ Nijmegen, Med Ctr, Dept Tumor Immunol, Nijmegen Ctr Mol Life Sci, Nijmegen, Netherlands

[25] St Louis Hosp, Hematol Transplantat, Paris, France

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2017年 / 23卷 / 01期

关键词：

Myelodysplastic syndrome; MDS; Acute myeloid leukemia; AML; Karnofsky performance status; CMV; HSCT; EBMT; Age; ACUTE MYELOID-LEUKEMIA; PROGNOSTIC SCORING SYSTEM; OLDER PATIENTS; COMORBIDITY INDEX; PHASE-III; GROUP-B; AZACITIDINE; CLASSIFICATION; OUTCOMES; REGIMENS;

D O I：

10.1016/j.bbmt.2016.09.027

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this retrospective analysis we evaluated the outcome of 313 patients aged >= 70 years in the registry of the European Group for Blood and Marrow Transplantation with myelodysplastic syndrome (MDS; n = 221) and secondary acute myeloid leukemia (n = 92) who underwent allogeneic hematopoietic stem cell transplantation (HSCT) from related (n = 79) or unrelated (n = 234) donors. Median age at HSCT was 72 years (range, 70 to 78). Conditioning regimen was nonmyeloablative (n = 54), reduced intensity (n = 207), or standard intensity (n = 52). Allogeneic HSCT for MDS patients >= 70 years was increasingly performed over time. Although during 2000 to 2004 only 16 patients received HSCT, during 2011 to 2013 the number of transplantations increased to 181. The cumulative incidence of nonrelapse mortality at 1 year and relapse at 3 years was 32% and 28%, respectively, with a 3-year overall survival rate of 34%. Good performance, determined by Karnofsky performance status, and recipients' seronegativity for cytomegalovirus was associated with 3-year estimated overall survival rates of 43% (P =.01) and 46% (P =.002), respectively. Conditioning intensity did not impact survival. After careful patient selection, allogeneic HSCT can be offered to patients older than >= 70 years with MDS. (C) 2017 American Society for Blood and Marrow Transplantation.

引用

页码：44 / 52

页数：9

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