Core-shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application

被引：91

作者：

Prabhakar, Neeraj ^{[1
,2
,3
,4
]}

Nareoja, Tuomas ^{[5
]}

von Haartman, Eva ^{[1
]}

Sen Karaman, Didem ^{[1
]}

Jiang, Hua ^{[6
]}

Koho, Sami ^{[5
]}

Dolenko, Tatiana A. ^{[7
]}

Hanninen, Pekka E. ^{[5
]}

Vlasov, Denis I. ^{[8
]}

Ralchenko, Victor G. ^{[8
]}

Hosomi, Satoru ^{[9
]}

Vlasov, Igor I. ^{[8
]}

Sahlgren, Cecilia ^{[2
,3
,4
,10
]}

Rosenholm, Jessica M. ^{[1
]}

机构：

[1] Abo Akad Univ, Dept Nat Sci, Phys Chem Lab, Ctr Funct Mat, SF-20500 Turku, Finland

[2] Univ Turku, Turku Ctr Biotechnol, FI-20521 Turku, Finland

[3] Abo Akad Univ, FI-20521 Turku, Finland

[4] Abo Akad Univ, Dept Biosci, FI-20520 Turku, Finland

[5] Univ Turku, Fac Med, Lab Biophys, FI-20520 Turku, Finland

[6] Aalto Univ, Nanomicroscopy Ctr, FI-00076 Espoo, Finland

[7] Moscow MV Lomonosov State Univ, Moscow 119991, Russia

[8] Russian Acad Sci, Inst Gen Phys, Moscow 119991, Russia

[9] TOMEI DIAMOND Co Ltd, Oyama, Tochigi 3230807, Japan

[10] Tech Univ Eindhoven, Dept Biomed Engn, NL-2612 Eindhoven, Netherlands

来源：

NANOSCALE | 2013年 / 5卷 / 09期

基金：

芬兰科学院;

关键词：

FLUORESCENT NANODIAMONDS; NANOPARTICLES; VACANCY; SINGLE; PARTICLES; NITROGEN; CENTERS;

D O I：

10.1039/c3nr33926b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recent advances within materials science and its interdisciplinary applications in biomedicine have emphasized the potential of using a single multifunctional composite material for concurrent drug delivery and biomedical imaging. Here we present a novel composite material consisting of a photoluminescent nanodiamond (ND) core with a porous silica (SiO2) shell. This novel multifunctional probe serves as an alternative nanomaterial to address the existing problems with delivery and subsequent tracing of the particles. Whereas the unique optical properties of ND allows for long-term live cell imaging and tracking of cellular processes, mesoporous silica nanoparticles (MSNs) have proven to be efficient drug carriers. The advantages of both ND and MSNs were hereby integrated in the new composite material, ND@MSN. The optical properties provided by the ND core rendered the nanocomposite suitable for microscopy imaging in fluorescence and reflectance mode, as well as super-resolution microscopy as a STED label; whereas the porous silica coating provided efficient intracellular delivery capacity, especially in surface-functionalized form. This study serves as a demonstration how this novel nanomaterial can be exploited for both bioimaging and drug delivery for future theranostic applications.

引用

页码：3713 / 3722

页数：10

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