共 24 条
Genetic and Pharmacological Inhibition of Rheb1-mTORC1 Signaling Exerts Cardioprotection against Adverse Cardiac Remodeling in Mice
被引:66
作者:

Wu, Xiangqi
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China
Nanjing Univ, Minist Educ, Model Anim Res Ctr, Key Lab Model Anim Dis Study, Nanjing 210061, Jiangsu, Peoples R China Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China

Cao, Yunshan
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China
Nanjing Univ, Minist Educ, Model Anim Res Ctr, Key Lab Model Anim Dis Study, Nanjing 210061, Jiangsu, Peoples R China Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China

Nie, Junwei
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Minist Educ, Model Anim Res Ctr, Key Lab Model Anim Dis Study, Nanjing 210061, Jiangsu, Peoples R China Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China

Liu, Hailang
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Minist Educ, Model Anim Res Ctr, Key Lab Model Anim Dis Study, Nanjing 210061, Jiangsu, Peoples R China Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China

Lu, Shuangshuang
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Minist Educ, Model Anim Res Ctr, Key Lab Model Anim Dis Study, Nanjing 210061, Jiangsu, Peoples R China Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China

Hu, Xiaoshan
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Minist Educ, Model Anim Res Ctr, Key Lab Model Anim Dis Study, Nanjing 210061, Jiangsu, Peoples R China Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China

Zhu, Jingai
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Minist Educ, Model Anim Res Ctr, Key Lab Model Anim Dis Study, Nanjing 210061, Jiangsu, Peoples R China Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China

Zhao, Xia
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Minist Educ, Model Anim Res Ctr, Key Lab Model Anim Dis Study, Nanjing 210061, Jiangsu, Peoples R China Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China

Chen, Jiandong
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ Tradit Chinese Med, Jiangsu Prov Tradit Chinese Med Hosp Affiliated, Nanjing, Jiangsu, Peoples R China Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China

Chen, Xiaohu
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ Tradit Chinese Med, Jiangsu Prov Tradit Chinese Med Hosp Affiliated, Nanjing, Jiangsu, Peoples R China Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China

Yang, Zhongzhou
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Univ, Minist Educ, Model Anim Res Ctr, Key Lab Model Anim Dis Study, Nanjing 210061, Jiangsu, Peoples R China Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China

Li, Xinli
论文数: 0 引用数: 0
h-index: 0
机构:
Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China
机构:
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China
[2] Nanjing Univ, Minist Educ, Model Anim Res Ctr, Key Lab Model Anim Dis Study, Nanjing 210061, Jiangsu, Peoples R China
[3] Nanjing Univ Tradit Chinese Med, Jiangsu Prov Tradit Chinese Med Hosp Affiliated, Nanjing, Jiangsu, Peoples R China
基金:
中国国家自然科学基金;
关键词:
MYOCARDIAL-INFARCTION;
HEART-FAILURE;
ASTRAGALOSIDE IV;
RAPAMYCIN;
KINASE;
HYPERTROPHY;
ACTIVATION;
PROTECTION;
AGONISTS;
GROWTH;
D O I:
10.1016/j.ajpath.2013.02.012
中图分类号:
R36 [病理学];
学科分类号:
100104 ;
摘要:
A previous study indicated that Rheb1 is required for mammalian target of TOR complex 1 (mTORC1) signaling in the brain. However, the function of Rheb1 in the heart is still elusive. In the present study, we deleted Rheb1 specifically in cardiomyocytes and found that reduced Rheb1 levels conferred cardioprotection against pathologic remodeling in myocardial infarction (MI) and pressure overload (transverse aortic constriction) mouse models. Cardiomyocyte apoptosis was reduced and mTORC1 activity was suppressed in cardiomyocyte Rheb/-deletion mice, suggesting that Rheb1 regulates mTORC1 activation in myocardium. Furthermore, we demonstrated that astragaloside IV (As-IV) could inhibit mTORC1, and As-IV treatment displayed similar protection against MI and transverse aortic constriction as Rheb1 genetic inhibition. This study indicates that Rheb1 is essential for mTORC1 activation in cardiomyocytes and suggests that targeting Rheb1-mTORC1 signaling, such as by As-IV treatment, may be an effective therapeutic method for treating patients with adverse cardiac remodeling after MI and hypertrophy.
引用
收藏
页码:2005 / 2014
页数:10
相关论文
共 24 条
[11]
Effect of Astragaloside IV on Hepatic Glucose-regulating Enzymes in Diabetic Mice Induced by a High-fat Diet and Streptozotocin
[J].
Lv, Lin
;
Wu, Shao-Yu
;
Wang, Guang-Fa
;
Zhang, Jia-Jie
;
Pang, Jian-Xin
;
Liu, Zhong-Qiu
;
Xu, Wei
;
Wu, Shu-Guang
;
Rao, Jin-Jun
.
PHYTOTHERAPY RESEARCH,
2010, 24 (02)
:219-224

Lv, Lin
论文数: 0 引用数: 0
h-index: 0
机构:
So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China

Wu, Shao-Yu
论文数: 0 引用数: 0
h-index: 0
机构:
So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China

Wang, Guang-Fa
论文数: 0 引用数: 0
h-index: 0
机构:
So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China

Zhang, Jia-Jie
论文数: 0 引用数: 0
h-index: 0
机构:
So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China

Pang, Jian-Xin
论文数: 0 引用数: 0
h-index: 0
机构:
So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China

Liu, Zhong-Qiu
论文数: 0 引用数: 0
h-index: 0
机构:
So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China

Xu, Wei
论文数: 0 引用数: 0
h-index: 0
机构:
So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China

Wu, Shu-Guang
论文数: 0 引用数: 0
h-index: 0
机构:
So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China

Rao, Jin-Jun
论文数: 0 引用数: 0
h-index: 0
机构:
So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China So Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China
[12]
Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy
[J].
McMullen, JR
;
Shioi, T
;
Zhang, L
;
Tarnavski, O
;
Sherwood, MC
;
Dorfman, AL
;
Longnus, S
;
Pende, M
;
Martin, KA
;
Blenis, J
;
Thomas, G
;
Izumo, S
.
MOLECULAR AND CELLULAR BIOLOGY,
2004, 24 (14)
:6231-6240

McMullen, JR
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Div Cardiovasc, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

Shioi, T
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Div Cardiovasc, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

Zhang, L
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Div Cardiovasc, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

Tarnavski, O
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Div Cardiovasc, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

Sherwood, MC
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Div Cardiovasc, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

Dorfman, AL
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Div Cardiovasc, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

Longnus, S
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Div Cardiovasc, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

论文数: 引用数:
h-index:
机构:

Martin, KA
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Div Cardiovasc, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

Blenis, J
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Div Cardiovasc, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

Thomas, G
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Div Cardiovasc, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

Izumo, S
论文数: 0 引用数: 0
h-index: 0
机构: Harvard Univ, Div Cardiovasc, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA
[13]
17 beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload
[J].
Patten, Richard D.
;
Pourati, Isaac
;
Aronovitz, Mark J.
;
Alsheikh-Ali, Alawi
;
Eder, Sarah
;
Force, Thomas
;
Mendelsohn, Michael E.
;
Karas, Richard H.
.
JOURNAL OF CARDIAC FAILURE,
2008, 14 (03)
:245-253

Patten, Richard D.
论文数: 0 引用数: 0
h-index: 0
机构:
Tufts Univ New England Med Ctr, Dept Med, Mol Cardiol Res Inst, Boston, MA 02111 USA Tufts Univ New England Med Ctr, Dept Med, Mol Cardiol Res Inst, Boston, MA 02111 USA

Pourati, Isaac
论文数: 0 引用数: 0
h-index: 0
机构:
Tufts Univ New England Med Ctr, Dept Med, Mol Cardiol Res Inst, Boston, MA 02111 USA Tufts Univ New England Med Ctr, Dept Med, Mol Cardiol Res Inst, Boston, MA 02111 USA

Aronovitz, Mark J.
论文数: 0 引用数: 0
h-index: 0
机构:
Tufts Univ New England Med Ctr, Dept Med, Mol Cardiol Res Inst, Boston, MA 02111 USA Tufts Univ New England Med Ctr, Dept Med, Mol Cardiol Res Inst, Boston, MA 02111 USA

Alsheikh-Ali, Alawi
论文数: 0 引用数: 0
h-index: 0
机构:
Tufts Univ New England Med Ctr, Dept Med, Mol Cardiol Res Inst, Boston, MA 02111 USA Tufts Univ New England Med Ctr, Dept Med, Mol Cardiol Res Inst, Boston, MA 02111 USA

Eder, Sarah
论文数: 0 引用数: 0
h-index: 0
机构:
Tufts Univ New England Med Ctr, Dept Med, Mol Cardiol Res Inst, Boston, MA 02111 USA Tufts Univ New England Med Ctr, Dept Med, Mol Cardiol Res Inst, Boston, MA 02111 USA

Force, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
Jefferson Med Coll, Ctr Translat Res, Philadelphia, PA USA Tufts Univ New England Med Ctr, Dept Med, Mol Cardiol Res Inst, Boston, MA 02111 USA

Mendelsohn, Michael E.
论文数: 0 引用数: 0
h-index: 0
机构:
Tufts Univ New England Med Ctr, Dept Med, Mol Cardiol Res Inst, Boston, MA 02111 USA Tufts Univ New England Med Ctr, Dept Med, Mol Cardiol Res Inst, Boston, MA 02111 USA

Karas, Richard H.
论文数: 0 引用数: 0
h-index: 0
机构:
Tufts Univ New England Med Ctr, Dept Med, Mol Cardiol Res Inst, Boston, MA 02111 USA Tufts Univ New England Med Ctr, Dept Med, Mol Cardiol Res Inst, Boston, MA 02111 USA
[14]
β-adrenergic agonists regulate Na-K-ATPase via p70S6k
[J].
Pesce, L
;
Comellas, A
;
Sznajder, JI
.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY,
2003, 285 (04)
:L802-L807

Pesce, L
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Feinberg Sch Med, Div Pulm & Crit Care Med, Chicago, IL 60611 USA Northwestern Univ, Feinberg Sch Med, Div Pulm & Crit Care Med, Chicago, IL 60611 USA

Comellas, A
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Feinberg Sch Med, Div Pulm & Crit Care Med, Chicago, IL 60611 USA Northwestern Univ, Feinberg Sch Med, Div Pulm & Crit Care Med, Chicago, IL 60611 USA

Sznajder, JI
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Feinberg Sch Med, Div Pulm & Crit Care Med, Chicago, IL 60611 USA Northwestern Univ, Feinberg Sch Med, Div Pulm & Crit Care Med, Chicago, IL 60611 USA
[15]
Cardiac restricted overexpression of kinase-dead mammalian target of rapamycin (mTOR) mutant impairs the mTOR-mediated signaling and cardiac function
[J].
Shen, Wei-Hua
;
Chen, Zhuang
;
Shi, Shu
;
Chen, Hanying
;
Zhu, Wuqiang
;
Penner, Anne
;
Bu, Guixue
;
Li, Wei
;
Boyle, David W.
;
Rubart, Michael
;
Field, Loren J.
;
Abraham, Robert
;
Liechty, Edward A.
;
Shou, Weinian
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2008, 283 (20)
:13842-13849

Shen, Wei-Hua
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA

Chen, Zhuang
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA

Shi, Shu
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA

Chen, Hanying
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA

Zhu, Wuqiang
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA

Penner, Anne
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA

Bu, Guixue
论文数: 0 引用数: 0
h-index: 0
机构:
Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA

Li, Wei
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA

Boyle, David W.
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA

论文数: 引用数:
h-index:
机构:

Field, Loren J.
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA

Abraham, Robert
论文数: 0 引用数: 0
h-index: 0
机构:
Dept Oncol Discovery, Pearl River, NY 10965 USA Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA

Liechty, Edward A.
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA

Shou, Weinian
论文数: 0 引用数: 0
h-index: 0
机构:
Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pediat,Herman B Wells Ctr Pediat Res, Div Pediat Cardiol & Neonatol, Indianapolis, IN 46202 USA
[16]
Activation of p70S6 kinase by β-adrenoceptor agonists on adult cardiomyocytes
[J].
Simm, A
;
Schlüter, KD
;
Diez, C
;
Piper, HM
;
Hoppe, J
.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY,
1998, 30 (10)
:2059-2067

Simm, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Biozentrum, Theodor Boveri Inst Biowissensch, D-97074 Wurzburg, Germany

Schlüter, KD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Biozentrum, Theodor Boveri Inst Biowissensch, D-97074 Wurzburg, Germany

Diez, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Biozentrum, Theodor Boveri Inst Biowissensch, D-97074 Wurzburg, Germany

Piper, HM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Biozentrum, Theodor Boveri Inst Biowissensch, D-97074 Wurzburg, Germany

Hoppe, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wurzburg, Biozentrum, Theodor Boveri Inst Biowissensch, D-97074 Wurzburg, Germany
[17]
Rapamycin-Induced Hypophosphatemia and Insulin Resistance Are Associated With mTORC2 Activation and Klotho Expression
[J].
Tataranni, T.
;
Biondi, G.
;
Cariello, M.
;
Mangino, M.
;
Colucci, G.
;
Rutigliano, M.
;
Ditonno, P.
;
Schena, F. P.
;
Gesualdo, L.
;
Grandaliano, G.
.
AMERICAN JOURNAL OF TRANSPLANTATION,
2011, 11 (08)
:1656-1664

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:

Cariello, M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bari A Moro, Nephrol Dialysis & Transplantat Unit, Bari, Italy Univ Foggia, Dept Biomed Sci, Nephrol Dialysis & Transplantat Unit, Foggia, Italy

Mangino, M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bari A Moro, Nephrol Dialysis & Transplantat Unit, Bari, Italy Univ Foggia, Dept Biomed Sci, Nephrol Dialysis & Transplantat Unit, Foggia, Italy

Colucci, G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bari A Moro, Nephrol Dialysis & Transplantat Unit, Bari, Italy Univ Foggia, Dept Biomed Sci, Nephrol Dialysis & Transplantat Unit, Foggia, Italy

Rutigliano, M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bari A Moro, Dept Emergency & Organ Transplantat, Urol & Renal Transplant Unit, Bari, Italy Univ Foggia, Dept Biomed Sci, Nephrol Dialysis & Transplantat Unit, Foggia, Italy

论文数: 引用数:
h-index:
机构:

Schena, F. P.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bari A Moro, Nephrol Dialysis & Transplantat Unit, Bari, Italy Univ Foggia, Dept Biomed Sci, Nephrol Dialysis & Transplantat Unit, Foggia, Italy

Gesualdo, L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bari A Moro, Nephrol Dialysis & Transplantat Unit, Bari, Italy Univ Foggia, Dept Biomed Sci, Nephrol Dialysis & Transplantat Unit, Foggia, Italy

Grandaliano, G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Foggia, Dept Biomed Sci, Nephrol Dialysis & Transplantat Unit, Foggia, Italy Univ Foggia, Dept Biomed Sci, Nephrol Dialysis & Transplantat Unit, Foggia, Italy
[18]
Long-Term Trends in the Incidence of Heart Failure After Myocardial Infarction
[J].
Velagaleti, Raghava S.
;
Pencina, Michael J.
;
Murabito, Joanne M.
;
Wang, Thomas J.
;
Parikh, Nisha I.
;
D'Agostino, Ralph B.
;
Levy, Daniel
;
Kannel, William B.
;
Vasan, Ramachandran S.
.
CIRCULATION,
2008, 118 (20)
:2057-2062

Velagaleti, Raghava S.
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Framingham Heart Study, Framingham, MA 01702 USA NHLBI, Framingham Heart Study, Framingham, MA 01702 USA

Pencina, Michael J.
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Framingham Heart Study, Framingham, MA 01702 USA
Boston Univ, Dept Math & Stat, Boston, MA 02215 USA NHLBI, Framingham Heart Study, Framingham, MA 01702 USA

Murabito, Joanne M.
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Framingham Heart Study, Framingham, MA 01702 USA
Boston Univ, Sch Med, Gen Internal Med Sect, Boston Med Ctr, Boston, MA 02118 USA NHLBI, Framingham Heart Study, Framingham, MA 01702 USA

Wang, Thomas J.
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Framingham Heart Study, Framingham, MA 01702 USA
Harvard Univ, Sch Med, Dept Med, Massachusetts Gen Hosp,Div Cardiol, Boston, MA USA NHLBI, Framingham Heart Study, Framingham, MA 01702 USA

Parikh, Nisha I.
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Framingham Heart Study, Framingham, MA 01702 USA NHLBI, Framingham Heart Study, Framingham, MA 01702 USA

D'Agostino, Ralph B.
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Framingham Heart Study, Framingham, MA 01702 USA
Boston Univ, Dept Math & Stat, Boston, MA 02215 USA NHLBI, Framingham Heart Study, Framingham, MA 01702 USA

Levy, Daniel
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Framingham Heart Study, Framingham, MA 01702 USA
NHLBI, Ctr Populat Studies, Bethesda, MD 20892 USA
Boston Univ, Sch Med, Prevent Med Sect, Boston Med Ctr, Boston, MA 02118 USA
Boston Univ, Sch Med, Cardiol Sect, Boston Med Ctr, Boston, MA 02118 USA NHLBI, Framingham Heart Study, Framingham, MA 01702 USA

Kannel, William B.
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Framingham Heart Study, Framingham, MA 01702 USA NHLBI, Framingham Heart Study, Framingham, MA 01702 USA

Vasan, Ramachandran S.
论文数: 0 引用数: 0
h-index: 0
机构:
NHLBI, Framingham Heart Study, Framingham, MA 01702 USA
Boston Univ, Sch Med, Prevent Med Sect, Boston Med Ctr, Boston, MA 02118 USA
Boston Univ, Sch Med, Cardiol Sect, Boston Med Ctr, Boston, MA 02118 USA NHLBI, Framingham Heart Study, Framingham, MA 01702 USA
[19]
Calcineurin inhibitors and rapamycin:: cancer protection or promotion?
[J].
Weischer, Maren
;
Roecken, Martin
;
Berneburg, Mark
.
EXPERIMENTAL DERMATOLOGY,
2007, 16 (05)
:385-393

Weischer, Maren
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tubingen, Dept Dermatol & Venerol, Phototherapy & Photodiagnost Unit, D-72076 Tubingen, Germany

Roecken, Martin
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tubingen, Dept Dermatol & Venerol, Phototherapy & Photodiagnost Unit, D-72076 Tubingen, Germany

Berneburg, Mark
论文数: 0 引用数: 0
h-index: 0
机构: Univ Tubingen, Dept Dermatol & Venerol, Phototherapy & Photodiagnost Unit, D-72076 Tubingen, Germany
[20]
Dosage-dependent effects of Akt1/protein kinase Bα (PKBα) and Akt3/PKBγ on thymus, skin, and cardiovascular and nervous system development in mice
[J].
Yang, ZZ
;
Tschopp, O
;
Di-Poï, N
;
Bruder, E
;
Baudry, A
;
Dümmler, B
;
Wahli, W
;
Hemmings, BA
.
MOLECULAR AND CELLULAR BIOLOGY,
2005, 25 (23)
:10407-10418

Yang, ZZ
论文数: 0 引用数: 0
h-index: 0
机构: Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland

论文数: 引用数:
h-index:
机构:

Di-Poï, N
论文数: 0 引用数: 0
h-index: 0
机构: Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland

Bruder, E
论文数: 0 引用数: 0
h-index: 0
机构: Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland

论文数: 引用数:
h-index:
机构:

Dümmler, B
论文数: 0 引用数: 0
h-index: 0
机构: Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland

Wahli, W
论文数: 0 引用数: 0
h-index: 0
机构: Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland

Hemmings, BA
论文数: 0 引用数: 0
h-index: 0
机构: Friedrich Miescher Inst Biomed Res, CH-4002 Basel, Switzerland