Novel approach towards the synthesis of 3,3a,4,5-tetrahydroquinolino-[4,3-c]isoxazole derivatives:: Application to the preparation of previously unattainable 3a,4-dihydroazabenzopyrano[4,3-c]isoxazole scaffolds

被引：4
作者：
Alcázar, J [1 ]
Alonso, JM [1 ]
Andrés, JI [1 ]
Bartolomé, JM [1 ]
Fernández, J [1 ]
机构：
[1] Janssen Cilag SA, Johnson & Johnson Pharmaceut Res & Dev Div, Toledo 45007, Spain
来源：
SYNLETT | 2005年 / 20期
关键词：
isoxazolines; fused-ring systems; ring closure; heterocycles; antidepressants;
D O I：
10.1055/s-2005-921909
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel synthetic approach towards the preparation of 3-substituted-7,8-dimethoxy-3,3a,4,5-tetrahydroquinolino[4,3-c]isoxazole derivatives is reported. Further application of this methodology to the preparation of previously unattainable 3a,4-dihydroazabenzopyrano[4,3-c]isoxazole derivatives is also described.
引用
收藏
页码：3139 / 3141
页数：3
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