Supercritical fluid extraction of Vitex agnus castus fruit

被引：34

作者：

Cossuta, D. ^{[1
]}

Simandi, B. ^{[1
]}

Vagi, E. ^{[1
]}

Hohmann, J. ^{[2
]}

Prechl, A. ^{[1
]}

Lemberkovics, E. ^{[3
]}

Kery, A. ^{[3
]}

Keve, T. ^{[4
]}

机构：

[1] Budapest Univ Technol & Econ, Dept Chem & Environm Proc Engn, H-1521 Budapest, Hungary

[2] Univ Szeged, Dept Pharmacognosy, H-6720 Szeged, Hungary

[3] Semmelweis Univ, Dept Pharmacognosy, H-1085 Budapest, Hungary

[4] Gradiens Ltd, H-1143 Budapest, Hungary

来源：

JOURNAL OF SUPERCRITICAL FLUIDS | 2008年 / 47卷 / 02期

基金：

美国国家科学基金会;

关键词：

Vitex agnus castus; Supercritical fluid extraction; Casticin; Triterpene; Diterpene;

D O I：

10.1016/j.supflu.2008.07.014

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The effects of supercritical fluid extraction (SFE) conditions (pressure and temperature) on extraction yield and recoveries of biologically active components were studied using a 3(2) full factorial design. Pilot plant SFE experiments were performed in a 5 x 10(-3) m(3) Volume high-pressure vessel. The pressure and temperature were varied over the ranges of 100-450 bar and 40-60 degrees C, respectively. The yield and recoveries were compared to those obtained with n-hexane and ethanol (96%, v/v) extractions. The extract samples were analysed by TLC, TLC-densitometry, GC and HPLC methods. The obtained yields changed between 1.9 and 65.7 g kg(-1), according to the solvent power of the supercritical fluid. The recoveries of the different minor components were (g minor components kg(-1) dried raw material): 0.06-1.06 rotundifurane, 0.02-1.08 beta-sitosterol, 0.04-0.63 beta-amyrin, 0.87-2.71 casticin. By evaluation the designed experiments 450 bar and 45 degrees C were chosen as the best conditions within the ranges investigated. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：188 / 194

页数：7

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