Feasibility of oncology clinical trial-embedded evaluation of social determinants of health

被引：13

作者：

Aziz-Bose, Rahela ^{[1
,2
,3
]}

Zheng, Daniel J. ^{[4
,5
]}

Umaretiya, Puja J. ^{[1
,2
,3
,6
]}

Ilcisin, Lenka ^{[1
,2
,7
,8
]}

Stevenson, Kristen ^{[1
]}

Koch, Victoria ^{[1
]}

Valenzuela, Ariana ^{[1
]}

Cole, Peter D. ^{[9
]}

Gennarini, Lisa M. ^{[10
]}

Kahn, Justine M. ^{[11
]}

Kelly, Kara M. ^{[12
]}

Thai-Hoa Tran ^{[13
]}

Michon, Bruno ^{[14
]}

Welch, Jennifer J. G. ^{[15
]}

Silverman, Lewis B. ^{[1
,2
,3
]}

Wolfe, Joanne ^{[2
,3
,6
]}

Bona, Kira ^{[1
,2
,3
,16
]}

机构：

[1] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

[2] Boston Childrens Hosp, Div Pediat Hematol Oncol, Boston, MA USA

[3] Harvard Med Sch, Boston, MA 02115 USA

[4] Childrens Hosp Philadelphia, Div Hematol, Philadelphia, PA 19104 USA

[5] Childrens Hosp Philadelphia, Div Oncol, Philadelphia, PA 19104 USA

[6] Dana Farber Canc Inst, Dept Psychosocial Oncol & Palliat Care, Boston, MA 02115 USA

[7] Boston Childrens Hosp, Dept Pediat Surg, Boston, MA USA

[8] Brigham & Womens Hosp, Dept Surg, 75 Francis St, Boston, MA 02115 USA

[9] Rutgers Canc Inst New Jersey, Div Pediat Hematol Oncol, New Brunswick, NJ USA

[10] Montefiore Med Ctr, Div Pediat Hematol Oncol & Blood & Marrow Cell Tr, 111 E 210th St, Bronx, NY 10467 USA

[11] Columbia Univ, Irving Med Ctr, Div Pediat Hematol Oncol & Stem Cell Transplantat, New York, NY USA

[12] Roswell Pk Comprehens Canc Ctr, Dept Pediat, Buffalo, NY USA

[13] Univ Montreal, Charles Bruneau Canc Ctr, Div Pediat Hematol Oncol, CHU Ste Justine, Montreal, PQ, Canada

[14] Ctr Hosp Univ Quebec, Dept Pediat, Ste Foy, PQ, Canada

[15] Brown Univ, Hasbro Childrens Hosp, Div Pediat Hematol Oncol, Providence, RI 02912 USA

[16] Dana Farber Canc Inst, Div Populat Sci, Boston, MA 02115 USA

来源：

PEDIATRIC BLOOD & CANCER | 2022年 / 69卷 / 11期

基金：

美国国家卫生研究院;

关键词：

health equity; research methods; social determinants of health;

D O I：

10.1002/pbc.29933

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Social determinants of health (SDoH) are associated with stark disparities in cancer outcomes, but systematic SDoH data collection is virtually absent from oncology clinical trials. Trial-based SDoH data are essential to ensure representation of marginalized populations, contextualize outcome disparities, and identify health-equity intervention opportunities. We report the feasibility of a pediatric oncology multicenter therapeutic trial-embedded SDoH investigation. Among 448 trial participants, 392 (87.5%) opted-in to the embedded SDoH study; 375 (95.7%) completed baseline surveys, with high longitudinal response rates (88.9-93.1%) over 24 months. Trial-embedded SDoH data collection is feasible and acceptable and must be consistently included within future oncology trials.

引用

页数：5

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