Label-free surface-enhanced Raman spectroscopy of biofluids: fundamental aspects and diagnostic applications

被引:172
作者
Bonifacio, Alois [1 ]
Cervo, Silvia [2 ,3 ]
Sergo, Valter [1 ]
机构
[1] Univ Trieste, Raman Spect Lab, Dept Engn & Architecture, I-34127 Trieste, TS, Italy
[2] Natl Canc Inst, CRO Aviano, CRO Biobank, I-33081 Aviano, PN, Italy
[3] Natl Canc Inst, CRO Aviano, Clin Canc Pathol, I-33081 Aviano, PN, Italy
关键词
SERS; Raman; Biofluids; Diagnosis; BLOOD-PLASMA; SILVER NANOPARTICLES; GOLD NANOPARTICLES; CANCER DETECTION; SINGLE-MOLECULE; SCATTERING SERS; URINE; RESONANCE; NANOSTRUCTURES; ERYTHROCYTE;
D O I
10.1007/s00216-015-8697-z
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
In clinical practice, one objective is to obtain diagnostic information while minimizing the invasiveness of the tests and the pain for the patients. To this end, tests based on the interaction of light with readily available biofluids including blood, urine, or saliva are highly desirable. In this review we examine the state of the art regarding the use of surface-enhanced Raman spectroscopy (SERS) to investigate biofluids, focusing on diagnostic applications. First, a critical evaluation of the experimental aspects involved in the collection of SERS spectra is presented; different substrate types are introduced, with a clear distinction between colloidal and non-colloidal metal nanostructures. Then the effect of the excitation wavelength is discussed, along with anomalous bands and artifacts which might affect SERS spectra of biofluids. The central part of the review examines the literature available on the SERS spectra of blood, plasma, serum, urine, saliva, tears, and semen. Finally, diagnostic applications are critically discussed in the context of the published evidence; this section clearly reveals that SERS of biofluids is most promising as a rapid, cheap, and non-invasive tool for mass screening for cancer.
引用
收藏
页码:8265 / 8277
页数:13
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