A Current Snapshot of Common Genomic Variants Contribution in Psychiatric Disorders

被引：5
|
作者：
Santoro, Marcos L. [1 ,2 ,3 ]
Moretti, Patricia N. [1 ,2 ,3 ]
Pellegrino, Renata [4 ]
Gadelha, Ary [1 ,2 ]
Abilio, Vanessa C. [1 ,2 ,5 ]
Hayashi, Mirian A. F. [1 ,2 ,5 ]
Belangero, Sintia I. [1 ,2 ,3 ]
Hakonarson, Hakon [4 ]
机构：
[1] Fed Univ Sao Paulo UNIFESP, Interdisciplinary Lab Clin Neurosci, Sao Paulo, SP, Brazil
[2] Fed Univ Sao Paulo UNIFESP, Dept Psychiat, Sao Paulo, SP, Brazil
[3] Fed Univ Sao Paulo UNIFESP, Div Genet, Sao Paulo, SP, Brazil
[4] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA
[5] Fed Univ Sao Paulo UNIFESP, Dept Pharmacol, Sao Paulo, SP, Brazil
来源：
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2016年 / 171卷 / 08期
基金：
巴西圣保罗研究基金会;
关键词：
GWAS; psychiatry; polygenic risk score; psychiatric disorder; COPY NUMBER VARIATION; WIDE ASSOCIATION; LITHIUM PROPHYLAXIS; BIPOLAR DISORDER; GENOMEWIDE ASSOCIATION; GENETIC-RELATIONSHIP; POLYGENIC RISK; SCHIZOPHRENIA; METAANALYSIS; AUTISM;
D O I：
10.1002/ajmg.b.32475
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
In the past decade, numerous advances were achieved in psychiatric genetics. Particularly, the genome wide association studies (GWAS) have contributed to uncovering new genes and pathways associated to psychiatric disorders (PDs). At the same time, with increasing sample sizes in the GWAS, the polygenic risk score (PRS) promoted an additional tool for identification and evaluation the genetic risk quantitatively in PDs. This concept review presents the state of the art GWAS analysis and PRS focusing on the genetic underpinnings of PDs. (C) 2016 Wiley Periodicals, Inc.
引用
收藏
页码：997 / 1005
页数：9
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