Molecular Diversity Sculpted by Fungal PKS-NRPS Hybrids

被引:174
作者
Boettger, Daniela [1 ]
Hertweck, Christian [1 ,2 ]
机构
[1] HKI, Leibniz Inst Nat Prod Res & Infect Biol, Dept Biomol Chem, D-07745 Jena, Germany
[2] Univ Jena, Chair Nat Prod Res, Jena, Germany
关键词
cytochalasin; lovastatin; nonribosomal peptides; polyketides; pseurotin A; CYCLOPIAZONIC ACID PRODUCTION; NONRIBOSOMAL PEPTIDE SYNTHETASES; BIOSYNTHETIC GENE-CLUSTER; CARBON CATABOLITE REPRESSION; POLYKETIDE SYNTHASE GENES; FUSARIUM-MONILIFORME; FUNCTIONAL-ANALYSIS; HETEROLOGOUS EXPRESSION; SECONDARY METABOLITES; ASPERGILLUS-TERREUS;
D O I
10.1002/cbic.201200624
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Fungal polyketide synthase-nonribosomal peptide synthetase (PKS-NRPS) hybrids manufacture a wide range of structurally diverse secondary metabolites that play an eminent role in the environment, as molecular tools and leads for therapeutic development. To date, a dozen PKS-NRPS megasynthetases can be linked to the corresponding secondary metabolites, which stand out because of their structural complexity. The diversity of their structures, biological activities, and biosynthetic routes are particularly intriguing considering the iterative use of the catalytic domains of the biosynthetic enzymes-implying an enigmatic biosynthetic code. This review provides an overview of the characterized fungal PKS-NRPS hybrids, their manifold functionalities, and the diversity of the resulting secondary metabolites, as well as molecular engineering attempts that highly improved the understanding of their cryptic programming.
引用
收藏
页码:28 / 42
页数:15
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