Enhanced dopamine release by nicotine in cigarette smokers: a double-blind, randomized, placebo-controlled pilot study

被引：40

作者：

Takahashi, Hidehiko ^{[1
]}

Fujimura, Yota ^{[1
]}

Hayashi, Mika ^{[2
]}

Takano, Harumasa ^{[1
]}

Kato, Motoichiro ^{[2
]}

Okubo, Yoshiro ^{[3
]}

Kanno, Iwao ^{[1
]}

Ito, Hiroshi ^{[1
]}

Suhara, Tetsuya ^{[1
]}

机构：

[1] Natl Inst Radiol Sci, Mol Imaging Ctr, Dept Mol Neuroimaging, Inage Ku, Chiba 2638555, Japan

[2] Keio Univ, Sch Med, Dept Neuropsychiat, Shinjuku Ku, Tokyo, Japan

[3] Nippon Med Sch, Dept Neuropsychiat, Bunkyo Ku, Tokyo 113, Japan

来源：

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2008年 / 11卷 / 03期

关键词：

dependence; dopamine; nicotine; positron emission tomography; striatum;

D O I：

10.1017/S1461145707008103

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Previous studies of smoking on dopamine release in humans were investigated only in smokers. Using nicotine gum, we examined the effect of nicotine on dopamine release in smokers and non-smokers and its relation to the degree of nicotine dependence. Smokers and non-smokers participated in a double-blind, randomized, placebo-controlled cross-over study. They participated in two PET measurements with [C-11]raclopride, in which they received either nicotine or placebo. Changes in [C-11]raclopride nondisplaceable binding potential (BPND) following nicotine administration were quantified. Smokers showed significant decrease in BP in the striatum following nicotine administration, but non-smokers did not show such a decrease. The BPND difference between the two scanning sessions was correlated with the degree of nicotine dependence. The BPND difference might reflect enhanced dopamine release in smokers and the reinforced effect of nicotine. These data suggest the feasibility of our gum method as well as the importance of the degree of dependence in future studies of the nicotine effect on the dopamine system.

引用

页码：413 / 417

页数：5

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