Role of the Na+/H+ exchanger on the development of diabetes mellitus and its chronic complications

被引：13

作者：

Sun, Yan-Ming ^{[1
]}

Su, Ying ^{[2
]}

Li, Jia ^{[1
]}

Tian, Ye ^{[1
]}

Wang, Lan-Feng ^{[1
]}

机构：

[1] Harbin Med Univ, Dept Cardiac, Affiliated Hosp 1, Care Unit, Harbin 150001, Peoples R China

[2] Harbin Med Univ, Dept Endocrinol, Affiliated Hosp 1, Harbin 150001, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2012年 / 427卷 / 02期

关键词：

Diabetes mellitus; Na+/H+ exchanger; Diabetic nephropathy; Cardiovascular complications; PANCREATIC BETA-CELLS; SODIUM/HYDROGEN EXCHANGER; MOLECULAR PHYSIOLOGY; INSULIN-RELEASE; GLUCOSE; PH; INHIBITION; MECHANISMS; ISLETS; ACID;

D O I：

10.1016/j.bbrc.2012.09.050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Micro- and macrovascular complications are the main cause of morbidity and mortality in diabetes mellitus. The Na+/H+ exchanger (NHE) is a family of proteins which exchange Na+ for H+ according to their concentration gradients in an electroneutral manner. The exchanger also plays a key role in several other cellular functions including proliferation, differentiation, apoptosis, migration, and cytoskeletal organization. Since not much is known on the relationship between NHE and diabetes mellitus, this review outlines the contribution of NHE to chronic complications of diabetes mellitus, such as diabetic nephropathy; diabetic cardiomyopathy. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：229 / 231

页数：3

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