Biocatalysts for multicomponent Biginelli reaction: bovine serum albumin triggered waste-free synthesis of 3,4-dihydropyrimidin-2-(1H)-ones

被引：50
|
作者：
Sharma, Upendra K. [1 ]
Sharma, Nandini [1 ]
Kumar, Rajesh [1 ]
Sinha, Arun K. [1 ]
机构：
[1] CSIR, CSIR Inst Himalayan Bioresource Technol, Nat Plant Prod Div, Palampur 176061, Himachal Prades, India
来源：
AMINO ACIDS | 2013年 / 44卷 / 03期
关键词：
Biginelli condensation; Bovine Serum Albumin; Biocatalysis; Sustainable Chemistry; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; CATALYZED SYNTHESIS; CINNAMIC-ACIDS; IONIC LIQUID; LIPASE; GREEN; DIHYDROPYRIMIDONES; CONDENSATION; ELIMINATION;
D O I：
10.1007/s00726-012-1437-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bovine serum albumin (BSA) promoted simple and efficient one-pot procedure was developed for the direct synthesis of 3,4-dihydropyrimidin-2(1H)-ones including potent mitotic kinesin Eg5 inhibitor monastrol under mild reaction conditions. The catalyst recyclability and gram scale synthesis have also been demonstrated to enhance the practical utility of process.
引用
收藏
页码：1031 / 1037
页数：7
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