Electrocatalytic activity of activated niclosamide on multi-walled carbon nanotubes glassy carbon electrode toward NADH oxidation

被引：6

作者：

Lopes, Cleylton Bezerra ^{[1
,2
,5
]}

dos Santos Silva, Francisco de Assis ^{[3
,5
]}

Lima, Phabyanno Rodrigues ^{[2
,5
]}

de Freitas, Johnnatan Duarte ^{[2
]}

Sousa, Jonas dos Santos ^{[2
]}

Kubota, Lauro Tatsuo ^{[4
,5
]}

Fonseca Goulart, Marilia Oliveira ^{[1
,5
]}

机构：

[1] Univ Fed Alagoas UFAL, IQB, BR-57072970 Maceio, AL, Brazil

[2] IFAL, Inst Fed Educ Ciencia & Tecnol Alagoas, BR-57020600 Maceio, AL, Brazil

[3] IFG, Inst Fed Educ Ciencia & Tecnol Goias, BR-76400000 Uruacu, Go, Brazil

[4] Univ Estadual Campinas, Inst Quim, BR-13084971 Campinas, SP, Brazil

[5] Univ Estadual Campinas, Inst Nacl Ciencia & Tecnol Bioanalit, BR-13084971 Campinas, SP, Brazil

来源：

JOURNAL OF SOLID STATE ELECTROCHEMISTRY | 2015年 / 19卷 / 09期

基金：

巴西圣保罗研究基金会;

关键词：

Sensors; Chemically modified electrode; Niclosamide; Mediators; MWCNT; NADH; NICOTINAMIDE ADENINE-DINUCLEOTIDE; VOLTAMMETRIC DETERMINATION; PASTE ELECTRODE; COMPOSITE; ACID; NANOPARTICLES; DERIVATIVES; MEDIATOR; DAMAGE;

D O I：

10.1007/s10008-015-2862-3

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

A simple and sensitive method for the electrocatalytic detection of dihydronicotinamide adenine dinucleotide (NADH) on an activated niclosamide (activatedNIC)-based modified electrode, prepared on a glassy carbon electrode modified with multi-walled carbon nanotubes (GCE/MWCNT/activatedNIC), was developed. This modified electrode shows efficient electrocatalytic oxidation activity toward NADH, at an applied potential of 0.065 V vs Ag/AgCl, with a kinetic constant, k (kin), of 1.15 x 10(4) L mol(-1) s(-1), evaluated by chronoamperometry. The sensor presents a linear response range from 10.0 up to 280.0 mu M with limits of detection and quantification and sensitivity of 3 mu M, 10 mu M, and 2.4 nA mu M-1, respectively.

引用

页码：2819 / 2829

页数：11

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