Effect of Histone Deacetylase Inhibitors on HIV Production in Latently Infected, Resting CD4+ T Cells From Infected Individuals Receiving Effective Antiretroviral Therapy

被引:81
作者
Blazkova, Jana
Chun, Tae-Wook [1 ]
Belay, Bietel W.
Murray, Danielle
Justement, J. Shawn
Funk, Emily K.
Nelson, Amy
Hallahan, Claire W.
Moir, Susan
Wender, Paul A. [2 ]
Fauci, Anthony S.
机构
[1] NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA
[2] Stanford Univ, Dept Chem, Stanford, CA 94305 USA
基金
美国国家卫生研究院;
关键词
VALPROIC ACID; RESERVOIR; PROSTRATIN; EXPRESSION; AIDS;
D O I
10.1093/infdis/jis412
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Persistence of the latent viral reservoir has been recognized as a major obstacle to eradicating human immunodeficiency virus (HIV) in infected individuals receiving antiretroviral therapy. It has been suggested that histone deacetylase inhibitors (HDACis) may purge HIV in the latent viral reservoir. However, the effect of HDACis on the degree and extent of HIV expression in the latent viral reservoir has not been fully delineated. Here we demonstrate that HDACis do not induce HIV production in the latent viral reservoir of aviremic individuals. Therefore, alternative therapeutic strategies may be necessary to eliminate HIV in the latent viral reservoir.
引用
收藏
页码:765 / 769
页数:5
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