There are many publications on theoretical analysis of deterministic difference equations and stochastic differential equations. However, relatively few theoretical papers are published to consider the positivity of solutions of discrete-time stochastic difference equations (DSDEs), and no theoretical papers investigate the global stability of nontrivial solutions of DSDEs with nonlinear terms. In this paper, we consider a DSDE model that is a generalization of two-dimensional nonlinear models of stochastic predator-prey interactions, and show the positivity and global stability of the nontrivial solutions by using our new discretized version of the Ito formula. In addition, our results are compared with those of continuous-time stochastic differential equations and discrete-time deterministic difference equations. Numerical simulations are introduced to support the results.