Porphyria cutanea tarda as a complication of therapy for chronic hepatitis C

被引：14
|
作者：
Azim, James [1 ,2 ]
McCurdy, Heather [1 ,2 ]
Moseley, Richard H. [1 ,2 ]
机构：
[1] Dept Vet Affairs Med Ctr, Div Gastroenterol, Dept Internal Med, Ann Arbor, MI USA
[2] Univ Michigan, Sch Med, Ann Arbor, MI USA
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2008年 / 14卷 / 38期
关键词：
Porphyria; Hepatitis C virus; Ribavirin; Pegylated interferon; Hemochromatosis;
D O I：
10.3748/wjg.14.5913
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
There is a strong association between porphyria cutanea tarda (PCT) and chronic viral hepatitis C. Therapy for chronic viral hepatitis C may improve PCT. However, there are only a few reports of the de novo development of PCT during therapy for chronic viral hepatitis C. We describe the development of PCT in a 56-year-old patient with chronic viral hepatitis C after 12 wk of peginterferon/ribavirin therapy. In addition, the patient was homozygous for the H63D hereditary hemochromatosis gene (HFE) mutation. The association of PCT with chronic viral hepatitis C and the possible role of hepatic iron overload and ribavirin-induced hemolytic anemia in the development of PCT during therapy for chronic viral hepatitis C are discussed. (C) 2008 The WIG Press. All rights reserved.
引用
收藏
页码：5913 / 5915
页数：3
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