Relief with Rapamycin: mTOR Inhibition Protects against Radiation-Induced Mucositis

被引：7
|
作者：
Finkel, Toren [1 ]
机构：
[1] NHLBI, Ctr Mol Med, NIH, Bethesda, MD 20892 USA
来源：
CELL STEM CELL | 2012年 / 11卷 / 03期
关键词：
HEMATOPOIETIC STEM-CELLS;
D O I：
10.1016/j.stem.2012.08.003
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
In this issue of Cell Stem Cell, Iglesias-Bartolome et al. (2012) show that mTOR inhibition with rapamycin protects against mucositis in mice, suggesting potential treatment strategies against this harmful side effect of anticancer therapies. In normal tissues, rapamycin prevents epithelial stem cell senescence by reducing oxidative stress through increased MnSOD.
引用
收藏
页码：287 / 288
页数：2
相关论文
共 50 条
  • [41] Probiotics in the management of radiation-induced oral mucositis
    Li, Yixuan
    Li, Zixia
    Zheng, Shuhao
    Xu, Xin
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2024, 14
  • [42] Sucralfate in the prevention of radiation-induced oral mucositis
    Cengiz, M
    Özyar, E
    Öztürk, D
    Akyol, F
    Atahan, IL
    Hayran, M
    JOURNAL OF CLINICAL GASTROENTEROLOGY, 1999, 28 (01) : 40 - 43
  • [43] Prevention of radiation-induced oral mucositis with benzydamine
    Ehab Y. Hanna
    Current Oncology Reports, 2002, 4 (1) : 65 - 67
  • [44] Pathogenesis and Amelioration of Radiation-Induced Oral Mucositis
    Charles T. Lee
    Thomas J. Galloway
    Current Treatment Options in Oncology, 2022, 23 : 311 - 324
  • [45] Breakdown of Symbiosis in Radiation-Induced Oral Mucositis
    Ingrosso, Gianluca
    Saldi, Simonetta
    Marani, Simona
    Wong, Alicia Y. W.
    Bertelli, Matteo
    Aristei, Cynthia
    Zelante, Teresa
    JOURNAL OF FUNGI, 2021, 7 (04)
  • [46] Mechanisms for radiation-induced oral mucositis and the consequences
    Shih, A
    Miaskowski, C
    Dodd, MJ
    Stotts, NA
    MacPhail, L
    CANCER NURSING, 2003, 26 (03) : 222 - 229
  • [47] Modulation of radiation-induced oral mucositis by thalidomide
    Frings, Katharina
    Gruber, Sylvia
    Kuess, Peter
    Kleiter, Miriam
    Doerr, Wolfgang
    STRAHLENTHERAPIE UND ONKOLOGIE, 2016, 192 (08) : 561 - 568
  • [48] A rat model of radiation-induced gi mucositis
    King, Gregory L.
    FASEB JOURNAL, 2011, 25
  • [49] Pathogenesis and Amelioration of Radiation-Induced Oral Mucositis
    Lee, Charles T.
    Galloway, Thomas J.
    CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2022, 23 (03) : 311 - 324
  • [50] Microvascular Changes in Radiation-Induced Oral Mucositis
    Hamilton, Scott
    Yoo, John
    Hammond, Alexander
    Read, Nancy
    Venkatesan, Varagur
    Franklin, Jason
    Fung, Kevin
    Gray, Daryl
    Parry, Neil
    Van Diepen, Kristen
    Baswick, Brenda Lee
    Badhwar, Amit
    JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY, 2008, 37 (05): : 730 - 737
12345