Strong Motion Deficits in Dyslexia Associated with DCDC2 Gene Alteration

被引：30

作者：

Cicchini, Guido Marco ^{[1
]}

Marino, Cecilia ^{[2
,3
,4
]}

Mascheretti, Sara ^{[2
]}

Perani, Daniela ^{[5
,6
]}

Morrone, Maria Concetta ^{[7
,8
]}

机构：

[1] CNR, Inst Neurosci, I-56124 Pisa, Italy

[2] IRCCS Eugenio Medea, Inst Sci, Child Psychopathol Unit, I-23842 Bosisio Parini, Lecco, Italy

[3] Univ Sante Mentale Quebec, Ctr Rech Inst, Quebec City, PQ G1J 2G3, Canada

[4] Univ Laval, Fac Med, Dept Psychiat & Neurosci, Quebec City, PQ G1V 0A6, Canada

[5] Univ Vita Salute San Raffaele, Hosp San Raffaele, Dept Nucl Med, I-20132 Milan, Italy

[6] Ist Sci San Raffaele, Div Neurosci, I-20132 Milan, Italy

[7] Univ Pisa, Dept Translat Res New Technol Med & Surg, I-56127 Pisa, Italy

[8] Sci Inst Stella Maris, I-56128 Pisa, Italy

来源：

JOURNAL OF NEUROSCIENCE | 2015年 / 35卷 / 21期

关键词：

DCDC2; dyslexia; magnocellular; psychophysics; visual motion; DEVELOPMENTAL DYSLEXIA; CONTRAST SENSITIVITY; MAGNOCELLULAR DEFECT; READING-DISABILITY; COHERENT MOTION; SUSCEPTIBILITY; CHILDREN; POLYMORPHISM; READERS; ADULTS;

D O I：

10.1523/JNEUROSCI.5077-14.2015

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dyslexia is a specific impairment in reading that affects 1 in 10 people. Previous studies have failed to isolate a single cause of the disorder, but several candidate genes have been reported. We measured motion perception in two groups of dyslexics, with and without a deletion within the DCDC2 gene, a risk gene for dyslexia. We found impairment for motion particularly strong at high spatial frequencies in the population carrying the deletion. The data suggest that deficits in motion processing occur in a specific genotype, rather than the entire dyslexia population, contributing to the large variability in impairment of motion thresholds in dyslexia reported in the literature.

引用

页码：8059 / 8064

页数：6

共 44 条

[1] Disabled readers suffer from visual and auditory impairments but not from a specific magnocellular deficit [J].