Post-withdrawal changes in middle-latency auditory evoked potentials in abstinent human alcoholics

被引：10

作者：

Ahveninen, J ^{[1
]}

Jääskeläinen, IP

Pekkonen, E

Hallberg, A

Hietanen, M

Näätänen, R

Sillanaukee, P

机构：

[1] Univ Helsinki, Dept Psychol, Cognit Brain Res Unit, FIN-00014 Helsinki, Finland

[2] Univ Helsinki, Dept Neurol, Helsinki, Finland

[3] Univ Helsinki, Cent Hosp, BioMag Lab, Helsinki, Finland

[4] Pharmacia Upjohn AB Diagnost, Alcohol Related Dis, Uppsala, Sweden

[5] Univ Tampere, Sch Med, FIN-33101 Tampere, Finland

[6] Karolinska Inst, Sch Med, Stockholm, Sweden

[7] Jarvenpaa Social Hosp, A Clin Fdn, Jarvenpaa, Finland

来源：

NEUROSCIENCE LETTERS | 1999年 / 268卷 / 02期

基金：

芬兰科学院;

关键词：

alcoholism; brain; electroencephalography; event-related potentials; middle-latency auditory evoked potentials; withdrawal;

D O I：

10.1016/S0304-3940(99)00378-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated the effects of chronic alcoholism on middle-latency auditory evoked potentials (MAEP) in 14 male alcoholics with 1-6 weeks of abstinence (without other severe disorders) and 13 age-matched male social-drinker controls. The peak amplitude of a positive deflection (Pa) of the MAEP, peaking at about 30 ms post-stimulus, was significantly larger in the alcoholics than in the controls (P < 0.01), and notably, a significant negative correlation (r = -0.65) was observed between the Pa amplitude and duration of abstinence in the alcoholics. The present results suggest that the post-withdrawal brain hyperexcitability in the alcoholic brain, gradually recovering with abstinence, could be objectively and non-invasively studied with the MAEP. (C) 1999 Elsevier Science Ireland Ltd. Ail rights reserved.

引用

页码：57 / 60

页数：4

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