Fluxapyroxad induces developmental delay in zebrafish (Danio rerio)

被引：31

作者：

Li, Wenhua ^{[1
]}

Wu, Yaqin ^{[1
]}

Yuan, Mingrui ^{[1
]}

Liu, Xuan ^{[2
]}

机构：

[1] Huaqiao Univ, Key Lab Precis Med & Mol Diag Fujian Univ, Key Lab Xiamen Marine & Gene Drugs,Engn Res Ctr M, Sch Biomed Sci,Key Lab Fujian Mol Med,Minist Educ, Xiamen 361021, Peoples R China

[2] Xiamen Meixuanming Biotech Co, Xiamen 361021, Peoples R China

来源：

CHEMOSPHERE | 2020年 / 256卷

基金：

中国国家自然科学基金;

关键词：

Fluxapyroxad; Zebrafish; Embryo; Developmental malformation; Developmental toxicity; Oxidative stress; OXIDATIVE STRESS; SDHI FUNGICIDES; HOMEOBOX GENE; EXPRESSION; GASTRULATION; PENTHIOPYRAD; THIFLUZAMIDE; GLUTATHIONE; RESISTANCE; DIVERSITY;

D O I：

10.1016/j.chemosphere.2020.127037

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Succinate dehydrogenase inhibitor (SDHI) fungicides are extensively used in agriculture. Some SDHI fungicides show developmental toxicity, immune toxicity and hepatotoxicity to fish. Fluxapyroxad (FLU) is a broad spectrum pyrazole-carboxamide SDHI fungicide and its potential impacts on fish embryonic development are unknown. We exposed zebrafish embryos to 1, 2 and 4 mM FLU. Developmental malformations, including yolk sac absorption disorder, decreased pigmentation and hatch delay were induced after FLU exposure. FLU caused significantly increased transcription levels in the ectoderm marker foxb1a but no significant changes in endoderm and mesoderm development markers (foxa2, ntl and eve1). Transcription levels of genes in the early stage embryos (gh, crx, neuroD and nkx2.4b) decreased significantly after FLU treatments. The content of glutathione (GSH) increased after FLU exposure. This study shows that FLU is toxic to zebrafish through its developmental effects and oxidative stress. FLU may pose risks to other non-target aquatic organisms. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：8

共 55 条

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