Accurate coarse-grained modeling of red blood cells

被引：298
|
作者：
Pivkin, Igor V. [1 ]
Karniadakis, George Em [1 ]
机构：
[1] Brown Univ, Div Appl Math, Providence, RI 02912 USA
来源：
PHYSICAL REVIEW LETTERS | 2008年 / 101卷 / 11期
关键词：
D O I：
10.1103/PhysRevLett.101.118105
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
We develop a systematic coarse-graining procedure for modeling red blood cells (RBCs) using arguments based on mean-field theory. The three-dimensional RBC membrane model takes into account the bending energy, in-plane shear energy, and constraints of fixed surface area and fixed enclosed volume. The coarse-graining procedure is general, it can be used for arbitrary level of coarse-graining and does not employ any fitting parameters. The sensitivity of the coarse-grained model is investigated and its behavior is validated against available experimental data and in dissipative particle dynamics (DPD) simulations of RBCs in capillary and shear flows.
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页数：4
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