Accurate coarse-grained modeling of red blood cells

被引：305

作者：

Pivkin, Igor V. ^{[1
]}

Karniadakis, George Em ^{[1
]}

机构：

[1] Brown Univ, Div Appl Math, Providence, RI 02912 USA

来源：

PHYSICAL REVIEW LETTERS | 2008年 / 101卷 / 11期

关键词：

D O I：

10.1103/PhysRevLett.101.118105

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We develop a systematic coarse-graining procedure for modeling red blood cells (RBCs) using arguments based on mean-field theory. The three-dimensional RBC membrane model takes into account the bending energy, in-plane shear energy, and constraints of fixed surface area and fixed enclosed volume. The coarse-graining procedure is general, it can be used for arbitrary level of coarse-graining and does not employ any fitting parameters. The sensitivity of the coarse-grained model is investigated and its behavior is validated against available experimental data and in dissipative particle dynamics (DPD) simulations of RBCs in capillary and shear flows.

引用

页数：4

共 28 条

[1] Swinging of red blood cells under shear flow [J].

Abkarian, Manouk ;

Faivre, Magalie ;

Viallat, Annie .

PHYSICAL REVIEW LETTERS, 2007, 98 (18)

[2] TOPOLOGY CHANGES IN FLUID MEMBRANES [J].

BOAL, DH ;

RAO, M .

PHYSICAL REVIEW A, 1992, 46 (06) :3037-3045

[3] NEGATIVE POISSON RATIO IN 2-DIMENSIONAL NETWORKS UNDER TENSION [J].

BOAL, DH ;

SEIFERT, U ;

SHILLCOCK, JC .

PHYSICAL REVIEW E, 1993, 48 (06) :4274-4283

[4] DUAL NETWORK MODEL FOR RED-BLOOD-CELL MEMBRANES [J].

BOAL, DH ;

SEIFERT, U ;

ZILKER, A .

PHYSICAL REVIEW LETTERS, 1992, 69 (23) :3405-3408

[5] MINIMUM ENERGY OF BENDING AS A POSSIBLE EXPLANATION OF BICONCAVE SHAPE OF HUMAN RED BLOOD CELL [J].

CANHAM, PB .

JOURNAL OF THEORETICAL BIOLOGY, 1970, 26 (01) :61-&

[6] Molecularly based analysis of deformation of spectrin network and human erythrocyte [J].

Dao, M. ;

Li, J. ;

Suresh, S. .

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 2006, 26 (08) :1232-1244

[7] Mechanics of the human red blood cell deformed by optical tweezers [J].

Dao, M ;

Lim, CT ;

Suresh, S .

JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS, 2003, 51 (11-12) :2259-2280

[8] Simulations of the erythrocyte cytoskeleton at large deformation. II. Micropipette aspiration [J].

Discher, DE ;

Boal, DH ;

Boey, SK .

BIOPHYSICAL JOURNAL, 1998, 75 (03) :1584-1597

[9] Large deformation of red blood cell ghosts in a simple shear flow [J].

Eggleton, CD ;

Popel, AS .

PHYSICS OF FLUIDS, 1998, 10 (08) :1834-1845

[10]

Evans E. A., 1980, MECH THERMODYNAMICS

← 1 2 3 →