A Case of Cobalamin Deficiency and Macrocytic Anemia Secondary to Sunitinib

被引：2

作者：

Reed, Jarred P. ^{[1
]}

Chung, Joan ^{[2
]}

Banerjee, Natasha ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Med Ctr, Olive View, Oncol, Sylmar, CA 91342 USA

[2] Univ Calif Los Angeles, Med Ctr, Olive View, Internal Med, Sylmar, CA 91342 USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2019年 / 11卷 / 03期

关键词：

sunitinib; macrocytic anemia; cobalamin; folate; toxicity; renal cell carcinoma; tyrosine kinase inhibitor;

D O I：

10.7759/cureus.4310

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sunitinib is an oral tyrosine kinase inhibitor (TKI) commonly used in the treatment of renal cell carcinoma (RCC). Among a broad range of toxicities, anemia and macrocytosis are common in patients treated with sunitinib. Correlation between sunitinib-associated macrocytosis and cobalamin deficiency has been reported in small case series and retrospective analyses, although others have not found an association. Here, we present a case of transfusion-dependent macrocytic anemia with cobalamin and folate deficiency in a patient with RCC treated with sunitinib.

引用

页数：4

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