Identification of Toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies

被引:90
作者
Beutler, B [1 ]
Du, X [1 ]
Poltorak, A [1 ]
机构
[1] Scripps Res Inst, Dept Immunol IMM 31, La Jolla, CA 92037 USA
来源
JOURNAL OF ENDOTOXIN RESEARCH | 2001年 / 7卷 / 04期
关键词
D O I
10.1179/096805101101532846
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:277 / 280
页数:4
相关论文
共 33 条
[1]   TLR4 mutations are associated with endotoxin hyporesponsiveness in humans [J].
Arbour, NC ;
Lorenz, E ;
Schutte, BC ;
Zabner, J ;
Kline, JN ;
Jones, M ;
Frees, K ;
Watt, JL ;
Schwartz, DA .
NATURE GENETICS, 2000, 25 (02) :187-+
[2]   The search for Lps:: 1993-1998 [J].
Beutler, B ;
Poltorak, A .
JOURNAL OF ENDOTOXIN RESEARCH, 2000, 6 (04) :269-293
[3]  
Bhat N, 1999, J IMMUNOL, V162, P7335
[4]   GENETIC DEFECT IN RESPONSIVENESS TO B-CELL MITOGEN LIPOPOLYSACCHARIDE [J].
COUTINHO, A ;
FORNI, L ;
MELCHERS, F .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1977, 7 (05) :325-328
[5]   SHARED ACTIONS OF ENDOTOXIN AND TAXOL ON TNF RECEPTORS AND TNF RELEASE [J].
DING, AH ;
PORTEU, F ;
SANCHEZ, E ;
NATHAN, CF .
SCIENCE, 1990, 248 (4953) :370-372
[6]   Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor [J].
Du, X ;
Poltorak, A ;
Silva, M ;
Beutler, B .
BLOOD CELLS MOLECULES AND DISEASES, 1999, 25 (21) :328-338
[7]   Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice [J].
Haziot, A ;
Ferrero, E ;
Kontgen, F ;
Hijiya, N ;
Yamamoto, S ;
Silver, J ;
Stewart, CL ;
Goyert, SM .
IMMUNITY, 1996, 4 (04) :407-414
[8]   A Toll-like receptor recognizes bacterial DNA [J].
Hemmi, H ;
Takeuchi, O ;
Kawai, T ;
Kaisho, T ;
Sato, S ;
Sanjo, H ;
Matsumoto, M ;
Hoshino, K ;
Wagner, H ;
Takeda, K ;
Akira, S .
NATURE, 2000, 408 (6813) :740-745
[9]   HIGH SUSCEPTIBILITY OF STRAIN A MICE TO ENDOTOXIN AND ENDOTOXIN-RED BLOOD CELL MIXTURES [J].
HEPPNER, G ;
WEISS, DW .
JOURNAL OF BACTERIOLOGY, 1965, 90 (03) :696-&
[10]  
Hoshino K, 1999, J IMMUNOL, V162, P3749