Identification of Toll-like receptor 4 (Tlr4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies

被引:96
作者
Beutler, B [1 ]
Du, X [1 ]
Poltorak, A [1 ]
机构
[1] Scripps Res Inst, Dept Immunol IMM 31, La Jolla, CA 92037 USA
来源
JOURNAL OF ENDOTOXIN RESEARCH | 2001年 / 7卷 / 04期
关键词
D O I
10.1179/096805101101532846
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:277 / 280
页数:4
相关论文
共 33 条
  • [1] TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
    Arbour, NC
    Lorenz, E
    Schutte, BC
    Zabner, J
    Kline, JN
    Jones, M
    Frees, K
    Watt, JL
    Schwartz, DA
    [J]. NATURE GENETICS, 2000, 25 (02) : 187 - +
  • [2] The search for Lps:: 1993-1998
    Beutler, B
    Poltorak, A
    [J]. JOURNAL OF ENDOTOXIN RESEARCH, 2000, 6 (04): : 269 - 293
  • [3] Bhat N, 1999, J IMMUNOL, V162, P7335
  • [4] GENETIC DEFECT IN RESPONSIVENESS TO B-CELL MITOGEN LIPOPOLYSACCHARIDE
    COUTINHO, A
    FORNI, L
    MELCHERS, F
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1977, 7 (05) : 325 - 328
  • [5] SHARED ACTIONS OF ENDOTOXIN AND TAXOL ON TNF RECEPTORS AND TNF RELEASE
    DING, AH
    PORTEU, F
    SANCHEZ, E
    NATHAN, CF
    [J]. SCIENCE, 1990, 248 (4953) : 370 - 372
  • [6] Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor
    Du, X
    Poltorak, A
    Silva, M
    Beutler, B
    [J]. BLOOD CELLS MOLECULES AND DISEASES, 1999, 25 (21) : 328 - 338
  • [7] Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice
    Haziot, A
    Ferrero, E
    Kontgen, F
    Hijiya, N
    Yamamoto, S
    Silver, J
    Stewart, CL
    Goyert, SM
    [J]. IMMUNITY, 1996, 4 (04) : 407 - 414
  • [8] A Toll-like receptor recognizes bacterial DNA
    Hemmi, H
    Takeuchi, O
    Kawai, T
    Kaisho, T
    Sato, S
    Sanjo, H
    Matsumoto, M
    Hoshino, K
    Wagner, H
    Takeda, K
    Akira, S
    [J]. NATURE, 2000, 408 (6813) : 740 - 745
  • [9] HIGH SUSCEPTIBILITY OF STRAIN A MICE TO ENDOTOXIN AND ENDOTOXIN-RED BLOOD CELL MIXTURES
    HEPPNER, G
    WEISS, DW
    [J]. JOURNAL OF BACTERIOLOGY, 1965, 90 (03) : 696 - &
  • [10] Hoshino K, 1999, J IMMUNOL, V162, P3749