Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

被引：1879
作者：
Minucci, S
Pelicci, PG
机构：
[1] European Inst Oncol, Dept Expt Oncol, I-20141 Milan, Italy
[2] Univ Milan, Dept Biomolecular Sci & Biotechnol, I-20100 Milan, Italy
[3] Univ Milan, Dept Med, I-20100 Milan, Italy
来源：
NATURE REVIEWS CANCER | 2006年 / 6卷 / 01期
关键词：
D O I：
10.1038/nrc1779
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Histone deacetylases ( HDACs) are considered to be among the most promising targets in drug development for cancer therapy, and first- generation histone deacetylase inhibitors ( HDACi) are currently being tested in phase I/ II clinical trials. A wide- ranging knowledge of the role of HDACs in tumorigenesis, and of the action of HDACi, has been achieved. However, several basic aspects are not yet fully understood. Investigating these aspects in the context of what we now understand about HDACi action both in vitro and in vivo will further improve the design of optimized clinical protocols.
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页码：38 / 51
页数：14
相关论文
共 141 条
[1]   Therapeutic implications of cancer stem cells [J].
Al-Hajj, M ;
Becker, MW ;
Wichal, M ;
Weissman, I ;
Clarke, MF .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2004, 14 (01) :43-47
[2]   ACETYLATION + METHYLATION OF HISTONES + THEIR POSSIBLE ROLE IN REGULATION OF RNA SYNTHESIS [J].
ALLFREY, VG ;
FAULKNER, R ;
MIRSKY, AE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1964, 51 (05) :786-+
[3]   p21WAF1 is required for butyrate-mediated growth inhibition of human colon cancer cells [J].
Archer, SY ;
Meng, SF ;
Shei, A ;
Hodin, RA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (12) :6791-6796
[4]  
Atadja Peter, 2004, Novartis Found Symp, V259, P249
[5]   RETRACTED: Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis (Retracted article. See vol. 142, pg. 1388, 2015) [J].
Bagheri-Yarmand, R ;
Talukder, AH ;
Wang, RA ;
Vadlamudi, RK ;
Kumar, R .
DEVELOPMENT, 2004, 131 (14) :3469-3479
[6]   Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90 - A novel basis for antileukemia activity of histone deacetylase inhibitors [J].
Bali, P ;
Pranpat, M ;
Bradner, J ;
Balasis, M ;
Fiskus, W ;
Guo, F ;
Rocha, K ;
Kumaraswamy, S ;
Boyapalle, S ;
Atadja, P ;
Seto, E ;
Bhalla, K .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (29) :26729-26734
[7]   Overexpression of histone deacetylase 1 confers resistance to sodium butyrate-mediated apoptosis in melanoma cells through a p53-mediated pathway [J].
Bandyopadhyay, D ;
Mishra, A ;
Medrano, EE .
CANCER RESEARCH, 2004, 64 (21) :7706-7710
[8]   Acetylation of importin-α nuclear import factors by CBP/p300 [J].
Bannister, AJ ;
Miska, EA ;
Görlich, D ;
Kouzarides, T .
CURRENT BIOLOGY, 2000, 10 (08) :467-470
[9]  
Beamish Heather, 2004, Methods Mol Biol, V281, P245
[10]   Acetylation inactivates the transcriptional repressor BCL6 [J].
Bereshchenko, OR ;
Gu, W ;
Dalla-Favera, R .
NATURE GENETICS, 2002, 32 (04) :606-613
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